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Literature summary for 3.4.21.98 extracted from

  • Poliakov, A.; Johansson, A.; Akerblom, E.; Oscarsson, K.; Samuelsson, B.; Hallberg, A.; Danielson, U.H.
    Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors (2004), Biochim. Biophys. Acta, 1672, 51-59.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitors with electrophilic C-terminal residues are generally non-selective while compounds with non-electrophilic C-terminal residues are more selective. Compounds with P1 aminobutyric acid residues are non-selective, while 1-aminocyclopropanecarboxylic acid and norvaline-based inhibitors are generally selective. Most potent and selective inhibitors contain a non-electrophilic phenyl acyl sulfonamide C-terminal residue Hepacivirus C
Suc-L-Asp-D-Glu-L-Leu-L-Ile-L-(cyclohexyl)Ala-1-aminocyclopropane-1-carboxylic acid comparison with inhibitory effect on human leukocyte elastase, porcine pancreatic elastase, bovine pancreatic chymotrypsin, and cathepsin B Hepacivirus C
Suc-L-Asp-D-Glu-L-Leu-L-Ile-L-(cyclohexyl)Ala-1-aminocyclopropane-1-carboxylic acid-COOH comparison with inhibitory effect on human leukocyte elastase, porcine pancreatic elastase, bovine pancreatic chymotrypsin, and cathepsin B Hepacivirus C
Suc-L-Asp-D-Glu-L-Leu-L-Ile-L-(cyclohexyl)Ala-1-aminocyclopropane-1-carboxylic acid-NHSO2Ph comparison with inhibitory effect on human leukocyte elastase, porcine pancreatic elastase, bovine pancreatic chymotrypsin, and cathepsin B Hepacivirus C
Suc-L-Asp-D-Glu-L-Leu-L-Ile-L-(cyclohexyl)Ala-L-2-aminovaleryl-NHSO2Ph comparison with inhibitory effect on human leukocyte elastase, porcine pancreatic elastase, bovine pancreatic chymotrypsin, and cathepsin B Hepacivirus C
Suc-L-Asp-D-Glu-L-Leu-L-Ile-L-(cyclohexyl)Ala-L-aminobutyryl ((S)-2-amino-butanoyl)-C2F5 comparison with inhibitory effect on human leukocyte elastase, porcine pancreatic elastase, bovine pancreatic chymotrypsin, and cathepsin B Hepacivirus C
Suc-L-Asp-D-Glu-L-Leu-L-Ile-L-(cyclohexyl)Ala-L-Cys-OH comparison with inhibitory effect on human leukocyte elastase, porcine pancreatic elastase, bovine pancreatic chymotrypsin, and cathepsin B Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
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