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Literature summary for 3.4.21.98 extracted from

  • Dansako, H.; Ikeda, M.; Ariumi, Y.; Wakita, T.; Kato, N.
    Double-stranded RNA-induced interferon-beta and inflammatory cytokine production modulated by hepatitis C virus serine proteases derived from patients with hepatic diseases (2009), Arch. Virol., 154, 801-810.
    View publication on PubMed
Search for more literature for 3.4.21.98

Application

Application Comment Organism
medicine inhibitory effects of NS3-4A on antiviral signaling pathways are limited to the Cardif-mediated pathway in human hepatocytes Hepacivirus C

Protein Variants

Protein Variants Comment Organism
S1165A mutant lacking serine protease activity does not cleave Cardif (adaptor protein of retinoic acid-inducible gene I or melanoma differentiation-associated gene-5) Hepacivirus C
W1528A mutant lacking RNA helicase activity cleaves Cardif (adaptor protein of retinoic acid-inducible gene I or melanoma differentiation-associated gene-5) Hepacivirus C

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CARDIF + H2O Hepacivirus C NS3-4A cleaves Cardif (adaptor protein of retinoic acid-inducible gene I or melanoma differentiation-associated gene-5), resulting in an interruption of the Cardif-mediated pathway in non-neoplastic human hepatocyte PH5CH8 cells ?
-
 ?
additional information Hepacivirus C NS3-4A lacks the ability to cleave endogenous TRIF, regardless of HCV strains derived from patients with different stages of hepatic disease. Inflammatory cytokine production by NF-kappaB activation via the TRIF-mediated pathway also remains unsuppressed by NS3-4A ?
-
 ?

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CARDIF + H2O NS3-4A cleaves Cardif (adaptor protein of retinoic acid-inducible gene I or melanoma differentiation-associated gene-5), resulting in an interruption of the Cardif-mediated pathway in non-neoplastic human hepatocyte PH5CH8 cells Hepacivirus C ?
-
 ?
additional information NS3-4A lacks the ability to cleave endogenous TRIF, regardless of HCV strains derived from patients with different stages of hepatic disease. Inflammatory cytokine production by NF-kappaB activation via the TRIF-mediated pathway also remains unsuppressed by NS3-4A Hepacivirus C ?
-
 ?

Synonyms

Synonyms Comment Organism
NS3 serine proteinase
-
 Hepacivirus C
NS3-4A
-
 Hepacivirus C