Literature summary for 3.4.21.98 extracted from

Chambers, T.J.; Droll, D.A.; Tang, Y.; Liang, Y.; Ganesh, V.K.; Murthy, K.H.; Nickells, M.
Yellow fever virus NS2B-NS3 protease: characterization of charged-to-alanine mutant and revertant viruses and analysis of polyprotein-cleavage activities (2005), J. Gen. Virol., 86, 1403-1413.

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Protein Variants

Protein Variants	Comment	Organism
additional information	series of 46 charged-to-alanine mutations in enzyme lead to four distinct phenotypes in cell culture: parental phenotype, reduced plaque-size, small plaque-size or no plaque formation. Mutations that reduce enzyme activity cause growth restriction of virus in cell culture. Protease domain is less tolerant to structural perturbation compared with the NS2B protein	Yellow fever virus

Organism

Organism	UniProt	Comment	Textmining
Yellow fever virus	-	-	-

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Release 2023.1 (January 2023)