Application | Comment | Organism |
---|---|---|
drug development | the epitopes B1, B8 and B9 are predicted to be ideal candidates for B-cell-based vaccine and are over 95% conserved across six major HCV genotypes. Determination of position and sequences of the peptides that may be used for development of peptide vaccines, overview | Hepacivirus C |
Cloned (Comment) | Organism |
---|---|
RNA sequence determination | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
six major HCV genotypes | - |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
nonstructural protein 3-4A serine protease | - |
Hepacivirus C |
nonstructural protein 3-4Agene | - |
Hepacivirus C |
NS34Agene | - |
Hepacivirus C |
NS3?4A | - |
Hepacivirus C |
General Information | Comment | Organism |
---|---|---|
evolution | the hepatitis C virus (HCV) is a plus stranded RNA virus belonging to the Flaviviridae family. Despite the high mutation rate of HCV, the functionally important residues are highly conserved. These include residues that form the catalytic triad (His57, Asp81, and Ser139), the S1 and S6 pocket, zinc-binding site (Cys97, Cys99, Cys145, and His149) and the substrate binding groove. The epitopes B1, B8 and B9 are over 95% conserved across six major HCV genotypes | Hepacivirus C |
additional information | the location of possible B- and T-cell epitopes are predicted in the HCV NS3-4A consensus sequence | Hepacivirus C |