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Literature summary for 3.4.21.98 extracted from

  • Liu, Y.; Saldivar, A.; Bess, J.; Solomon, L.; Chen, C.M.; Tripathi, R.; Barrett, L.; Richardson, P.L.; Molla, A.; Kohlbrenner, W.; Kati, W.
    Investigating the origin of the slow-binding inhibition of HCV NS3 serine protease by a novel substrate based inhibitor (2003), Biochemistry, 42, 8862-8869.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
C159S mutant enzyme displays wild-type catalytic activity and susceptibility to inhibition by the S-S linked inhibitor Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
2,2-Dihydroxy-indan-1,3-dione
-
Hepacivirus C
2-(4-Butyl-phenyl)-2-phenylsulfanyl-indan-1,3-dione IC50: 0.0017 mM Hepacivirus C
2-Hydroxy-2-(1-nitro-ethyl)-indan-1,3-dione
-
Hepacivirus C
2-Hydroxy-2-(2-nitro-cyclopentyl)-indan-1,3-dione
-
Hepacivirus C
2-Methyl-2-phenylsulfanyl-indan-1,3-dione IC50: 0.0036 mM Hepacivirus C
2-Phenyl-2-phenylsulfanyl-indan-1,3-dione IC50: 0.012 mM Hepacivirus C
2-Phenylsulfanyl-2-p-tolyl-indan-1,3-dione IC50: 0.0031 mM Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Hepacivirus C

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0017
-
IC50: 0.0017 mM Hepacivirus C 2-(4-Butyl-phenyl)-2-phenylsulfanyl-indan-1,3-dione
0.0031
-
IC50: 0.0031 mM Hepacivirus C 2-Phenylsulfanyl-2-p-tolyl-indan-1,3-dione
0.0036
-
IC50: 0.0036 mM Hepacivirus C 2-Methyl-2-phenylsulfanyl-indan-1,3-dione
0.012
-
IC50: 0.012 mM Hepacivirus C 2-Phenyl-2-phenylsulfanyl-indan-1,3-dione