Protein Variants | Comment | Organism |
---|---|---|
C159S | mutant enzyme displays wild-type catalytic activity and susceptibility to inhibition by the S-S linked inhibitor | Hepacivirus C |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2-Dihydroxy-indan-1,3-dione | - |
Hepacivirus C | |
2-(4-Butyl-phenyl)-2-phenylsulfanyl-indan-1,3-dione | IC50: 0.0017 mM | Hepacivirus C | |
2-Hydroxy-2-(1-nitro-ethyl)-indan-1,3-dione | - |
Hepacivirus C | |
2-Hydroxy-2-(2-nitro-cyclopentyl)-indan-1,3-dione | - |
Hepacivirus C | |
2-Methyl-2-phenylsulfanyl-indan-1,3-dione | IC50: 0.0036 mM | Hepacivirus C | |
2-Phenyl-2-phenylsulfanyl-indan-1,3-dione | IC50: 0.012 mM | Hepacivirus C | |
2-Phenylsulfanyl-2-p-tolyl-indan-1,3-dione | IC50: 0.0031 mM | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Hepacivirus C |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0017 | - |
IC50: 0.0017 mM | Hepacivirus C | 2-(4-Butyl-phenyl)-2-phenylsulfanyl-indan-1,3-dione | |
0.0031 | - |
IC50: 0.0031 mM | Hepacivirus C | 2-Phenylsulfanyl-2-p-tolyl-indan-1,3-dione | |
0.0036 | - |
IC50: 0.0036 mM | Hepacivirus C | 2-Methyl-2-phenylsulfanyl-indan-1,3-dione | |
0.012 | - |
IC50: 0.012 mM | Hepacivirus C | 2-Phenyl-2-phenylsulfanyl-indan-1,3-dione |