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Literature summary for 3.4.21.98 extracted from

  • Oliva, C.; Rodriguez, A.; Gonzalez, M.; Yang, W.
    A quantum mechanics/molecular mechanics study of the reaction mechanism of the hepatitis C virus NS3 protease with the NS5A/5B substrate (2007), Proteins, 66, 444-455.
    View publication on PubMed

Application

Application Comment Organism
drug development barrier state B1 is a relevant molecular structure to be considered in the design of new inhibitors of the NS3 enzyme. Residues Arg-109, Lys-136, Gly-137, Arg-155 and Asp-79 are responsible for the electrostatic stabilization of B1. The tetra-coordinated intermediate I1, may also be of interest as possible targets for the design of new drugs Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NS5A/5B + H2O
-
Hepacivirus C ?
-
?

Synonyms

Synonyms Comment Organism
NS3 protease
-
Hepacivirus C