Literature summary for 3.4.21.98 extracted from

Salloum, S.; Kluge, S.F.; Kim, A.Y.; Roggendorf, M.; Timm, J.
The resistance mutation R155K in the NS3/4A protease of hepatitis C virus also lead the virus to escape from HLA-A*68-restricted CD8 T cells (2010), Antiviral Res., 87, 272-275.

Search for more literature for 3.4.21.98

Protein Variants

Protein Variants	Comment	Organism
A156T	the mutant shows about 45% activity and is more resistant to the treatment with protease inhibitor BILN-2061 compared to the wild type enzyme	Hepacivirus C
R155K	the mutant shows about 80% activity and is more resistant to the treatment with protease inhibitor BILN-2061 compared to the wild type enzyme, the variant is associated with a relatively high replication level and with a substantial loss of cross-recognition by specific CD8 T cells targeting the epitope HAVGIFRAAV1175-1184	Hepacivirus C
R155Q	the mutant shows about 40% activity and is more resistant to the treatment with protease inhibitor BILN-2061 compared to the wild type enzyme	Hepacivirus C

Inhibitors

Inhibitors	Comment	Organism	Structure
BILN-2061	about 90% inhibition at 40 nM	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

Synonyms

Synonyms	Comment	Organism
NS3/4A protease	-	Hepacivirus C

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)