Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-aminocyclopropane-1-carboxylic acid ketoacid | electrophilic and acidic compound | Hepacivirus C | |
1-aminocyclopropane-1-carboxylic acid ketotetrazole | electrophilic and acidic compound | Hepacivirus C | |
1-aminocyclopropane-1-carboxylic acid pentafluoroethyl ketone | electrophilic and non-acidic compound | Hepacivirus C | |
1-aminocyclopropanecarboxylic acid | non-electrophilic and acidic compound | Hepacivirus C | |
L-aminobutyric acid carboxylic acid | non-electrophilic and acidic compound | Hepacivirus C | |
L-aminobutyric acid pentafluoroethyl ketone | electrophilic and non-acidic compound | Hepacivirus C | |
L-norvaline carboxylic acid | non-electrophilic and acidic compound | Hepacivirus C | |
L-norvaline ketotetrazole | electrophilic and acidic compound | Hepacivirus C | |
L-norvaline pentafluoroethyl ketone | electrophilic and non-acidic compound | Hepacivirus C | |
additional information | electrophilic compounds with a pentafluoroethyl ketone group show stronger inhibition at pH 8 than pH 6, the difference is only significant at high ionic strength. Electrophilic compounds with an acidic C-terminal group or a cyclic P1 residue show a lower inhibitory effect at pH 8 than at pH 6, inconsistent with a mechanism-based inhibition. All electrophilic compounds have a strong inhibition at pH 6, when mechanism-based inhibition is unlikely | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-DED-(EDANS)-EEAbupsi[COO]ASK(Dabcyl)-NH2 + H2O | - |
Hepacivirus C | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NS3 | - |
Hepacivirus C |
NS3 protease | - |
Hepacivirus C |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
KKGSVVIVGRIVLSGK | - |
Hepacivirus C |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000062 | - |
1-aminocyclopropanecarboxylic acid | at pH 6.0 | Hepacivirus C | |
0.000016 | - |
L-norvaline carboxylic acid | at pH 6.0 | Hepacivirus C | |
0.000025 | - |
1-aminocyclopropanecarboxylic acid | at pH 6.0 and 100 mM NaCl | Hepacivirus C | |
0.000031 | - |
L-norvaline carboxylic acid | at pH 6.0 and 100 mM NaCl | Hepacivirus C | |
0.000051 | - |
L-aminobutyric acid pentafluoroethyl ketone | at pH 8.0 and 100 mM NaCl | Hepacivirus C | |
0.000052 | - |
1-aminocyclopropane-1-carboxylic acid ketoacid | at pH 6.0 | Hepacivirus C | |
0.000084 | - |
L-aminobutyric acid pentafluoroethyl ketone | at pH 6.0 | Hepacivirus C | |
0.000098 | - |
L-aminobutyric acid carboxylic acid | at pH 6.0 | Hepacivirus C | |
0.000117 | - |
L-norvaline pentafluoroethyl ketone | at pH 8.0 and 100 mM NaCl | Hepacivirus C | |
0.000134 | - |
L-norvaline ketotetrazole | at pH 6.0 | Hepacivirus C | |
0.000145 | - |
L-norvaline pentafluoroethyl ketone | at pH 8.0 | Hepacivirus C | |
0.00015 | - |
L-norvaline pentafluoroethyl ketone | at pH 6.0 | Hepacivirus C | |
0.00015 | - |
L-aminobutyric acid pentafluoroethyl ketone | at pH 6.0 and 100 mM NaCl | Hepacivirus C | |
0.00019 | - |
1-aminocyclopropane-1-carboxylic acid ketoacid | at pH 6.0 and 100 mM NaCl | Hepacivirus C | |
0.0002 | - |
1-aminocyclopropanecarboxylic acid | at pH 8.0 and 100 mM NaCl | Hepacivirus C | |
0.000245 | - |
L-norvaline carboxylic acid | at pH 8.0 and 100 mM NaCl | Hepacivirus C | |
0.00025 | - |
L-aminobutyric acid carboxylic acid | at pH 6.0 and 100 mM NaCl | Hepacivirus C | |
0.00032 | - |
1-aminocyclopropanecarboxylic acid | at pH 8.0 | Hepacivirus C | |
0.00035 | - |
L-norvaline pentafluoroethyl ketone | at pH 6.0 and 100 mM NaCl | Hepacivirus C | |
0.00037 | - |
1-aminocyclopropane-1-carboxylic acid ketotetrazole | at pH 6.0 | Hepacivirus C | |
0.00045 | - |
L-norvaline carboxylic acid | at pH 8.0 | Hepacivirus C | |
0.00046 | - |
L-norvaline ketotetrazole | at pH 6.0 and 100 mM NaCl | Hepacivirus C | |
0.00082 | - |
L-aminobutyric acid pentafluoroethyl ketone | at pH 8.0 | Hepacivirus C | |
0.00107 | - |
1-aminocyclopropane-1-carboxylic acid ketotetrazole | at pH 6.0 and 100 mM NaCl | Hepacivirus C | |
0.00125 | - |
L-aminobutyric acid carboxylic acid | at pH 8.0 and 100 mM NaCl | Hepacivirus C | |
0.00149 | - |
1-aminocyclopropane-1-carboxylic acid pentafluoroethyl ketone | at pH 6.0 | Hepacivirus C | |
0.00168 | - |
1-aminocyclopropane-1-carboxylic acid pentafluoroethyl ketone | at pH 8.0 and 100 mM NaCl | Hepacivirus C | |
0.00174 | - |
L-norvaline ketotetrazole | at pH 8.0 | Hepacivirus C | |
0.00182 | - |
1-aminocyclopropane-1-carboxylic acid ketoacid | at pH 8.0 and 100 mM NaCl | Hepacivirus C | |
0.00188 | - |
L-norvaline ketotetrazole | at pH 8.0 and 100 mM NaCl | Hepacivirus C | |
0.00227 | - |
1-aminocyclopropane-1-carboxylic acid ketotetrazole | at pH 8.0 and 100 mM NaCl | Hepacivirus C | |
0.00275 | - |
L-aminobutyric acid carboxylic acid | at pH 8.0 | Hepacivirus C | |
0.0032 | - |
1-aminocyclopropane-1-carboxylic acid pentafluoroethyl ketone | at pH 6.0 and 100 mM NaCl | Hepacivirus C | |
0.00377 | - |
1-aminocyclopropane-1-carboxylic acid ketoacid | at pH 8.0 | Hepacivirus C | |
0.0041 | - |
1-aminocyclopropane-1-carboxylic acid pentafluoroethyl ketone | at pH 8.0 | Hepacivirus C | |
0.00562 | - |
1-aminocyclopropane-1-carboxylic acid ketotetrazole | at pH 8.0 | Hepacivirus C |