Literature summary for 3.4.21.98 extracted from

Ding, Q.; Huang, B.; Lu, J.; Liu, Y.J.; Zhong, J.
Hepatitis C virus NS3/4A protease blocks IL-28 production (2012), Eur. J. Immunol., 42, 2374-2382.

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Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

General Information

General Information	Comment	Organism
physiological function	viral NS3/4A protease activity is responsible for inhibition of hepatitis C virus genomic RNA-induced interferon IL-28 expression upon infection. Hepatitis C virus can trigger type III interferon expression in hosts. As a counter measurement, the virus blocks this antiviral response by using its own NS3/4A protease to target the key adaptor molecules that mediate the activation of NK-kappaB and IRF3	Hepacivirus C

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Release 2023.1 (January 2023)