Literature summary for 3.4.21.98 extracted from

Bondada, L.; Rondla, R.; Pradere, U.; Liu, P.; Li, C.; Bobeck, D.; McBrayer, T.; Tharnish, P.; Courcambeck, J.; Halfon, P.; Whitaker, T.; Amblard, F.; Coats, S.J.; Schinazi, R.F.
Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors (2013), Bioorg. Med. Chem. Lett., 23, 6325-6330.

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Inhibitors

Inhibitors	Comment	Organism	Structure
boceprevir	-	Hepacivirus C
N-[(1S)-1-cyclohexyl-2-[[(2S)-1-(2-{[1-cyclopropyl-4-(cyclopropylamino)-3,4-dioxobutan-2-yl]carbamoyl]-1',3'-dihydrospiro[cyclobutane-1,2'-inden]-3-yl)-3,3-dimethyl-1-oxobutan-2-yl]amino}-2-oxoethyl]pyrazine-2-carboxamide	compound displays an EC50 of 0.8 microM against hepatitis C virus with no toxicity in Huh7 and Vero cells at concentration up to 10 and 100 microM, respectively. Unfortunately, overall cytotoxicity in cell based systems discourages further development	Hepacivirus C
telaprevir	-	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

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Release 2023.1 (January 2023)