3.6.1.9: nucleotide diphosphatase
This is an abbreviated version!
For detailed information about nucleotide diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.9
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3.6.1.9
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ecosystem
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climate
-
forest
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accident
-
basophil
-
chernobyl
-
terrestrial
-
land
-
atmospheric
-
phosphorus
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grassland
-
aboveground
-
fukushima
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allergy
-
ribavirin
-
radionuclides
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phytase
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thiopurine
-
tibia
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belowground
-
ash
-
canopy
-
budget
-
boreal
-
biome
-
rbv
-
anti-ige
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modis
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interannual
-
meteorological
-
disaster
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arid
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azathioprine
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ukraine
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hydrological
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rainfall
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corn-soybean
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coniferous
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ectonucleotidases
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peg-ifn
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ntpdases
-
earthquake
-
croplands
-
ecto-nucleoside
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diphosphohydrolase
-
year-1
-
land-use
-
mercaptopurine
-
e-ntpdase
-
steppe
-
medicine
-
drug development
- 3.6.1.9
-
ecosystem
-
climate
-
forest
- accident
-
basophil
-
chernobyl
-
terrestrial
-
land
-
atmospheric
- phosphorus
-
grassland
-
aboveground
-
fukushima
- allergy
- ribavirin
-
radionuclides
- phytase
- thiopurine
-
tibia
-
belowground
- ash
-
canopy
-
budget
-
boreal
-
biome
- rbv
-
anti-ige
-
modis
-
interannual
-
meteorological
-
disaster
-
arid
- azathioprine
-
ukraine
-
hydrological
-
rainfall
-
corn-soybean
-
coniferous
- ectonucleotidases
-
peg-ifn
- ntpdases
-
earthquake
-
croplands
-
ecto-nucleoside
-
diphosphohydrolase
-
year-1
-
land-use
- mercaptopurine
- e-ntpdase
-
steppe
- medicine
- drug development
Reaction
Synonyms
ADPglucose pyrophosphatase/phosphodiesterase, AGPPase, AGPPase1, AGPPase2, alkaline sphingomyelinase nucleotide pyrophosphatase phosphodiesterase 7, Apyrase, ASMTL-Maf, BSU28050, CBS-PPase, CBS-pyrophosphatase, CD203c, CD39, diphosphopyridine nucleotide pyrophosphatase, dITP pyrophosphatase, dITPase, E-NPP, E-NPP1, E-NPP3, E-NTPDase, E-type ATPDase, EC 3.6.1.19, ecto-ATP-diphosphohydrolase, ecto-ATPDase, ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleoside triphosphate diphosphohydrolase 2, ecto-nucleotide phosphodiesterase/pyrophosphatase 6 eNPP6, ecto-nucleotide pyrophosphatase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-nucleotide pyrophosphatase/phosphodiesterase I-3, ecto-nucleotide pyrophosphatase/phosphodiesterase1, ecto-nucleotide pyrophosphatase/phosphodiesterase3, ecto-nucleotide pyrophosphatase/phosphodiesterases, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase family member 3, ENPP1, ENPP3, ENTPD1, Entpd6, family II pyrophosphatase, h-NPP-1, h-NPP-3, h-NPP1, h-NPP3, HAM1, inosine triphosphatase, inosine triphosphate pyrophosphatase, inosine triphosphate pyrophosphohydrolase, ITPA, ITPase, Maf protein, Maf-like protein YhdE, MazG, MazG protein, MazG-related protein, More, MutT, NPP, NPP 1, NPP 2, NPP 3, NPP-5, NPP1, NPP2, NPP3, NPP6, NPP7, NPPase, NPPr, NTPDase, nucleoside triphosphate diphosphatase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate pyrophosphatase, nucleoside triphosphate pyrophosphohydrolase, nucleoside-triphosphate pyrophosphatase, nucleotide pyrophosphastases/phosphodiesterases1, nucleotide pyrophosphastases/phosphodiesterases3, nucleotide pyrophosphatase, nucleotide pyrophosphatase-1, nucleotide pyrophosphatase-3, nucleotide pyrophosphatase-5, nucleotide pyrophosphatase/phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase NPP1, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-I, nucleotide pyrophosphatase/phosphodiesterases, nucleotide pyrophosphohydrolase, nucleotide-sugar pyrophosphatase, nucleotide-sugar pyrophosphatase/phosphodiesterase, ONPP, PC-1, plasma cell membrane glycoprotein-1, PPase, pyrophosphatase, nucleoside triphosphate, RdgB, RS21-C6, SAGPPase1, SAGPPase2, Tm-MazG, TM0159, TM0913, YhdE, YJR069C, YOR111W, ZmNPP1, ZmNPP2, ZmNPP3
ECTree
3.6.1.9 nucleotide diphosphataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.6.1.9 - nucleotide diphosphatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,4-dihydronicotinamide adenine dinucleotide + H2O
1,4-dihydronicotinamide mononucleotide + 5'-AMP
3 diadenosine 5',5''-P1,P4-tetraphosphate + 3 H2O
2 ATP + 2 ADP + 2 AMP
-
-
-
?
3-acetylpyridine adenine dinucleotide + H2O
3-acetylpyridine riboside 5'-phosphate + 5'-AMP
3-aminopyridine 1,N6-ethenoadenine dinucleotide + H2O
3-aminopyridine riboside + N6-etheneadenosine 5'-phosphate
-
-
-
?
3-methylpyridine adenine dinucleotide + H2O
3-methylpyridine mononucleotide + 5'-AMP
-
-
-
?
4-nitrophenyl phenyl phosphate + H2O
4-nitrophenol + phenyl phosphate
-
-
-
?
4-nitrophenyl phosphate monoanion + H2O
4-nitrophenol + phosphate
-
72fold higher activity than with 4-nitrophenyl phosphate dianion
-
-
?
4-nitrophenyl-5'-adenosine monophosphate + H2O
4-nitrophenol + 5'-adenosine monophosphate
artificial substrate
-
-
?
5'-deoxy-5'-thioadenosine 5'-triphosphate + H2O
5'-deoxy-5'-thioadenosine 3'-monophosphate + phosphate
-
-
-
?
7-methyl 5'-guanosine 2'-O-methylguanosine triphosphate + H2O
7-methyl 5'-guanosine 2'-O-methylguanosine diphosphate + phosphate
-
-
-
-
?
7-methyl 5'-guanosine 2'-O-methylgunaosine triphosphate + H2O
7-methyl-GMP + 7-methyl-GDP + GMP + GDP
-
-
-
?
8-bromo-NAD+ + H2O
8-bromo-AMP + NMN
-
same hydrolysis rate as for NAD+
-
?
adenosine (alpha,beta-methylene) 5'-triphosphate + H2O
adenosine (alpha,beta-methylene) 5'-diphosphate + phosphate
-
-
-
?
adenosine 3'-(alpha-naphthylphosphate)
adenosine + alpha-naphthylphosphate
-
very low activity
-
?
ADP-ribose + H2O
AMP + alpha-D-ribose 1-phosphate
99% of the activity with ADP-glucose
-
-
?
alpha-naphthylphosphate + H2O
alpha-naphthol + phosphate
-
low activity
-
?
beta,gamma-methyleneadenosine 5'-triphosphate + H2O
adenosine 5'-monophosphate + phosphomethylposphoric acid
bis(4-nitrophenyl) phosphate + H2O
4-nitrophenylphosphate + 4-nitrophenol
-
-
-
-
?
bis-4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
2000fold higher activity than with 4-nitrophenyl phosphate dianion
-
-
?
bis-p-nitrophenyl phosphate + H2O
p-nitrophenol + p-nitrophenyl phosphate
-
-
-
-
?
CDP-glucose + H2O
CMP + alpha-D-glucose 1-phosphate
77% of the activity with ADP-glucose
-
-
?
dGTP + H2O
dGMP + diphosphate
dGTP is the best substrate among the deoxyribonucleoside triphosphates
-
-
?
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano + 2 H2O
?
low hydrolysis activity with the inhibitor as substrate
-
-
?
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-gamma,delta-methylene-tetraphosphate + 2 H2O
?
low hydrolysis activity with the inhibitor as substrate
-
-
?
diadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano + 2 H2O
?
low hydrolysis activity with the inhibitor as substrate
-
-
?
diadenosine 5',5''-P1,P5-pentaposphate + H2O
ATP + ADP + AMP + adenosine 5'-tetraphosphate
-
-
-
?
diadenosine polyphosphate + H2O
AMP + ?
-
from di- to pentaphosphates, hydrolysis rate decreases with chain length
-
?
diphospho-3-acetylpyridine nucleotide + H2O
?
-
reduced form, 2fold higher activity than for NAD+
-
?
dITP + H2O
dIMP + diphosphate
at the optimal pH of 10.0, the recombinant enzyme hydrolyzes ITP, dITP, and xanthosine 5'-triphosphate to their respective monophosphates whereas activity with other nucleoside triphosphates is low. UTP, (d)CTP, TTP, and (d)ATP are hydrolyzed 10-100fold less than dITP. IDP and IMP are not hydrolyzed at all
-
-
?
GDP-mannose + H2O
GMP + alpha-D-mannose 1-phosphate
76% of the activity with ADP-glucose
-
-
?
guanosine (alpha,beta-methylene) 5'-triphosphate + H2O
guanosine (alpha,beta-methylene) 5'-diphosphate + phosphate
-
-
-
?
ITP + H2O
IMP + diphosphate
at the optimal pH of 10.0, the recombinant enzyme hydrolyzes ITP, dITP, and xanthosine 5'-triphosphate to their respective monophosphates whereas activity with other nucleoside triphosphates is low. UTP, (d)CTP, TTP, and (d)ATP are hydrolyzed 10-100fold less than dITP. IDP and IMP are not hydrolyzed at all
-
-
?
methyl 4-nitrophenyl phosphate + H2O
4-nitrophenol + methyl phosphate
-
200fold higher activity than with 4-nitrophenyl phosphate dianion
-
-
?
P1,P2-di(adenosine-5') diphosphate + H2O
?
-
tetramer 3fold more active than dimer
-
?
P1,P2-di(thymidine-3') diphosphate + H2O
?
-
very low activity for both dimer and tetramer
-
?
P1,P2-di(thymidine-5') diphosphate + H2O
?
-
low activity for both dimer and tetramer
-
?
P1,P3-di(adenosine-5') triphosphate + H2O
?
-
tetramer 2fold more active than dimer
-
?
P1,P4-bis(5'-adenosyl)-alpha,beta-gamma,delta-bismethylene-tetraphosphate + 2 H2O
?
low hydrolysis activity with the inhibitor as substrate
-
-
?
P1-5'-(7-methyl)-guanosine-P3-5'-guanosine triphosphate + H2O
7-methylguanosine 5'-diphosphate + GMP
-
cap analogue
-
?
thionicotinamide adenine dinucleotide + H2O
thionicotinamide mononucleotide + 5'-AMP
-
-
-
?
thymidine + alpha-naphthylphosphate + H2O
thymidine 3'-alpha-naphthol + phosphate
-
very low activity
-
?
thymidine 3'-alpha-naphthylphosphate + H2O
thymidine 3'-alpha-naphthol + phosphate
-
-
-
-
?
thymidine 3'-monophosphate p-nitrophenyl ester + H2O
thymidine 3'-monophosphate + p-nitrophenol
thymidine 5'-6-bromo-2-hydroxy-3-naphthoic acid 2-methoxyanilide-naphthylphosphate + H2O
?
-
low activity
-
?
thymidine 5'-diphospho 5'-thymidine + H2O
thymidine 5'-phosphate + thymidine 5'-phosphate
-
low activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
thymidine-5'-L-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
-
?
TTP + H2O
TMP + diphosphate
the enzyme exhibits significant activity for TTP only when substrate concentration reaches 0.5 mM
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + H2O
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP
uridine 3'-(alpha-naphthylphosphate) + H2O
uridine + alpha-naphthylphosphate
-
very low activity
-
?
uridine 3'-(phenylphosphate) + H2O
uridine + phenylphosphate
-
very low activity
-
?
uridine diphosphoglucose + H2O
UMP + D-glucose-1-phosphate
-
-
-
?
xanthosine 5'-triphosphate + H2O
xanthosine 5'-monophosphate + diphosphate
at the optimal pH of 10.0, the recombinant enzyme hydrolyzes ITP, dITP, and xanthosine 5'-triphosphate to their respective monophosphates whereas activity with other nucleoside triphosphates is low. UTP, (d)CTP, TTP, and (d)ATP are hydrolyzed 10-100fold less than dITP. IDP and IMP are not hydrolyzed at all
-
-
?
1,4-dihydronicotinamide adenine dinucleotide + H2O
1,4-dihydronicotinamide mononucleotide + 5'-AMP
-
-
-
?
1,4-dihydronicotinamide adenine dinucleotide + H2O
1,4-dihydronicotinamide mononucleotide + 5'-AMP
-
-
-
?
2',3'-cAMP + H2O
adenosine monophosphate
-
low activity for the tetramer
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
3'-phosphoadenosine + phosphosulfate
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
3'-phosphoadenosine + phosphosulfate
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
3'-phosphoadenosine + phosphosulfate
-
-
-
?
3-acetylpyridine adenine dinucleotide + H2O
3-acetylpyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
3-acetylpyridine adenine dinucleotide + H2O
3-acetylpyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
3-aminopyridine adenine dinucleotide + H2O
3-aminopyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
3-aminopyridine adenine dinucleotide + H2O
3-aminopyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
3-aminopyridine adenine dinucleotide + H2O
3-aminopyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
4-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
-
-
-
?
4-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
-
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
-
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
-
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
artificial substrate
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
artificial substrate
-
-
?
4-nitrophenyl-5'-thymidine monophosphate + H2O
4-nitrophenol + 5'-thymidine monophosphate
artificial substrate
-
-
?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
hydrolysis of pnp-TMP at the cell surface of both osteocarcinoma and colon cancer cells
-
-
?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
a specific NPP substrate
-
-
?
adenosine 5'-phosphosulfate + H2O
?
31% of the activity with ADP
-
-
?
adenosine 5'-phosphosulfate + H2O
?
44% of the activity with ADP-glucose
-
-
?
adenosine 5'-phosphosulfate + H2O
?
81% of the activity with UDP
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
best substrate
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
65% of the activity with ADP
-
-
?
ATP + H2O
ADP + phosphate
-
the specific activity of NPP for ATP is about 5fold higher than that of ADP
-
-
?
ATP + H2O
AMP + diphosphate
-
-
ADP formation as a result of adenylate kinase activity
?
ATP + H2O
AMP + diphosphate
-
accounts for 50-75% of extracellular hydrolysed ATP
-
?
ATP + H2O
AMP + diphosphate
-
extracellular ATP mainly hydrolysed by ecto-nucleotide pyrophosphatase, enzyme modulates purinoceptor-mediated signal transduction
-
?
beta,gamma-methyleneadenosine 5'-triphosphate + H2O
adenosine 5'-monophosphate + phosphomethylposphoric acid
-
-
-
?
beta,gamma-methyleneadenosine 5'-triphosphate + H2O
adenosine 5'-monophosphate + phosphomethylposphoric acid
-
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
32% of the activity with UDP
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
35% of the activity with UDP
-
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
-
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
0.31% hydrolysis rate compared to NADH as substrate
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
low activity
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
-
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
-
-
?
bis(p-nitrophenyl)phosphate + H2O
p-nitrophenol + p-nitrophenylphosphate
-
dimer nearly 4fold more active than tetramer
-
?
diadenosine 5',5''-P1,P3-triphosphate + H2O
5'-ADP + 5'-AMP
NPP3
-
-
?
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
ATP + 5'-AMP
NPP3
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
p4A + 5'-AMP
NPP3
-
-
?
diguanosine 5',5'''-P1,P4-tetraphosphate + H2O
GTP + 5'-GMP
NPP3
-
-
?
dTTP + H2O
dTMP + diphosphate
the enzyme possesses dTTP-specific activity at a substrate concentration of 0.1 mM
-
-
?
GTP + H2O
GMP + diphosphate
GTP is the best substrate among the ribonucleoside triphosphates
-
-
?
mRNA + H2O
7-methyl-GMP + ?
-
reovirus m7-G(5')p3(5')Gm-terminated intact mRNA
-
?
NADH + H2O
NMNH + AMP
-
reduced and oxidized forms, split by two different pyrophosphatase in the crude extract, oxidized form not split by the purified enzyme
-
?
NADH + H2O
NMNH + AMP
-
alpha-isomer, reduced activity for both reduced and oxidized forms
-
?
NADH + H2O
NMNH + AMP
-
best natural substrate, reduced form more rapidly hydrolysed than oxidized form
-
?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
-
only reduced form hydrolysed
-
?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
-
-
-
?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
-
-
-
?
NADPH + H2O
NMNH + adenosine 2',5'-phosphate
-
reduced form more rapidly hydrolysed than oxidized form
-
?
nicotinamide 1,N6-ethenoadenine dinucleotide + H2O
NMN + N6-ethenoadenosine 5'-phosphate
-
-
-
?
nicotinamide 1,N6-ethenoadenine dinucleotide + H2O
NMN + N6-ethenoadenosine 5'-phosphate
-
-
-
?
nicotinamide 1,N6-ethenoadenine dinucleotide + H2O
NMN + N6-ethenoadenosine 5'-phosphate
-
-
-
?
nicotinamide hypoxanthine dinucleotide + H2O
NMN + hypoxanthine monophosphate
-
-
-
?
nicotinamide hypoxanthine dinucleotide + H2O
NMN + hypoxanthine monophosphate
-
-
-
?
nicotinic acid adenine dinucleotide + H2O
nicotinic acid mononucleotide + 5'-AMP
-
-
-
?
nicotinic acid adenine dinucleotide + H2O
nicotinic acid mononucleotide + 5'-AMP
-
-
-
?
p-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + TMP
-
-
-
-
?
p-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + TMP
-
1500000fold higher activity than with 4-nitrophenyl phosphate dianion
-
-
?
p-nitrophenyl 5'-thymidine monophosphate + H2O
4-nitrophenol + TMP
-
-
-
-
?
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonate
-
phosphodiesterase-1 activity
-
?
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonate
-
phosphodiesterase-1 activity
-
?
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonate
-
low activity
-
?
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonate
-
dimer 8fold more active than tetramer
-
?
p-nitrophenylphosphate + H2O
p-nitrophenol + phosphate
-
0.04% hydrolysis rate compared to NADH as substrate
-
?
pyridine adenine dinucleotide + H2O
pyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
pyridine adenine dinucleotide + H2O
pyridine riboside 5'-phosphate + 5'-AMP
-
-
-
?
TDP-glucose + H2O
tMP + alpha-D-glucose 1-phosphate
15% of the activity with ADP
-
-
?
TDP-glucose + H2O
tMP + alpha-D-glucose 1-phosphate
82% of the activity with ADP-glucose
-
-
?
thymidine 3'-diphospho 3'-thymidine + H2O
thymidine 3'-phosphate + thymidine 3'-phosphate
-
-
-
?
thymidine 3'-diphospho 3'-thymidine + H2O
thymidine 3'-phosphate + thymidine 3'-phosphate
-
very low activity
-
?
thymidine 3'-monophosphate p-nitrophenyl ester + H2O
thymidine 3'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 3'-monophosphate p-nitrophenyl ester + H2O
thymidine 3'-monophosphate + p-nitrophenol
-
low activity
-
?
thymidine 3'-monophosphate p-nitrophenyl ester + H2O
thymidine 3'-monophosphate + p-nitrophenol
-
dimer 10fold more active than tetramer
-
?
thymidine 5'-alpha-naphthylphosphate + H2O
thymidine + alpha-naphthylphosphate
-
very low activity
-
?
thymidine 5'-alpha-naphthylphosphate + H2O
thymidine + alpha-naphthylphosphate
-
very low activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
significant phosphodiesterase activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
faster cleavage than other substrates tested
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
significant phosphodiesterase activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
significant phosphodiesterase activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
very low activity
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
-
-
?
thymidine 5'-monophosphate p-nitrophenyl ester + H2O
thymidine 5'-monophosphate + p-nitrophenol
-
equal activity for dimer and tetramer
-
?
UDP-glucose + H2O
UMP + alpha-D-glucose 1-phosphate
25% of the activity with ADP
-
-
?
UDP-glucose + H2O
UMP + alpha-D-glucose 1-phosphate
77% of the activity with ADP-glucose
-
-
?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
-
best substrate of nucleotide-sugars tested
-
?
UDP-glucuronic acid + H2O
UMP + glucuronic acid phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + H2O
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP
-
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + H2O
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
-
-
?
UTP + H2O
UMP + diphosphate
the enzyme exhibits significant activity for UTP only when substrate concentration reaches 0.5 mM
-
-
?
UTP + H2O
UMP + diphosphate
-
2fold higher hydrolysis rate than for ATP
-
?
additional information
?
-
-
the enzyme is not active upon AMP, GMP, dAMP, IMP, CMP, dGMP, dADP, TDP, TMP, UMP, dCMP, 3'-AMP, cAMP, and 4-nitrophenyl phosphate
-
-
?
additional information
?
-
-
the enzyme preferentially hydrolyzes nucleoside 5'-triphosphates over nucleoside 5'-diphosphates
-
-
?
additional information
?
-
-
nucleotide ester-forming alcoholytic activity
-
-
?
additional information
?
-
-
hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview
-
-
?
additional information
?
-
no activity with ATP, CTP, GTP, TDP, TMP, and dCTP
-
-
?
additional information
?
-
-
E-NPP3 is associated with carcinogenesis of human colon cancer
-
-
?
additional information
?
-
NPP1 hydrolyzes a wide range of phosphodiester bonds, e.g. in nucleoside triphosphates, (cyclic) dinucleotides, and nucleotide sugars yielding nucleoside 5'-monophosphates as products. Its main substrate is ATP which is cleaved to AMP and diphosphate. Purine nucleotides (ATP and GTP) are better substrates than pyrimidine nucleotides (CTP and UTP). Besides, NPP1 metabolizes other nucleotides, e.g. nicotinamide adenine dinucleotide (NAD+), 3'-phosphoadenosine-5'-phosphosulfate (PAPS), diadenosine polyphosphates like diadenosine triphosphate (AP3A) or diadenosine tetraphosphate (AP4A), and UDP-glucose
-
-
-
additional information
?
-
-
NPP1 hydrolyzes a wide range of phosphodiester bonds, e.g. in nucleoside triphosphates, (cyclic) dinucleotides, and nucleotide sugars yielding nucleoside 5'-monophosphates as products. Its main substrate is ATP which is cleaved to AMP and diphosphate. Purine nucleotides (ATP and GTP) are better substrates than pyrimidine nucleotides (CTP and UTP). Besides, NPP1 metabolizes other nucleotides, e.g. nicotinamide adenine dinucleotide (NAD+), 3'-phosphoadenosine-5'-phosphosulfate (PAPS), diadenosine polyphosphates like diadenosine triphosphate (AP3A) or diadenosine tetraphosphate (AP4A), and UDP-glucose
-
-
-
additional information
?
-
-
functional enzyme is required in carminerin-deficiency to suppress the resulting pathological endochondral ossifications
-
-
?
additional information
?
-
-
the enzyme does not hydrolyze pyridoxal 5'-phosphate
-
-
?
additional information
?
-
NPP1 hydrolyzes a wide range of phosphodiester bonds, e.g. in nucleoside triphosphates, (cyclic) dinucleotides, and nucleotide sugars yielding nucleoside 5'-monophosphates as products. Its main substrate is ATP which is cleaved to AMP and diphosphate. Purine nucleotides (ATP and GTP) are better substrates than pyrimidine nucleotides (CTP and UTP)
-
-
-
additional information
?
-
-
substrate specificity, overview. No activity with bis-4-nitrophenyl phosphate. FAD, ADP-ribose, ADPG, UDPG, some diadenosine polyphosphates (ApnAs), ATP, ADP, UDP and 3',5'-cAMP are poor or no substrates
-
-
?
additional information
?
-
-
isozyme NPP1 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP1 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP1 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
-
isozyme NPP2 does not recognize nucleotide sugars as substrates, but hydrolyzed UDP, ADP and adenosine 5'-phosphosulfate, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP2 does not recognize nucleotide sugars as substrates, but hydrolyzed UDP, ADP and adenosine 5'-phosphosulfate, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP2 does not recognize nucleotide sugars as substrates, but hydrolyzed UDP, ADP and adenosine 5'-phosphosulfate, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
-
isozyme NPP6 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP6 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
isozyme NPP6 exhibits hydrolytic activities toward ATP, UDP-glucose and the starch precursor molecule, ADP-glucose, no activity with hexose phosphates and mononucleotides
-
-
?
additional information
?
-
-
the enzyme is an oligomannosidic glycoprotein that may participate in neural cell communication
-
-
?
additional information
?
-
-
nucleotide ester-forming alcoholytic activity
-
-
?
additional information
?
-
NPP1 hydrolyzes a wide range of phosphodiester bonds, e.g. in nucleoside triphosphates, (cyclic) dinucleotides, and nucleotide sugars yielding nucleoside 5'-monophosphates as products. Its main substrate is ATP which is cleaved to AMP and diphosphate. Purine nucleotides (ATP and GTP) are better substrates than pyrimidine nucleotides (CTP and UTP)
-
-
-
additional information
?
-
-
nucleotide ester-forming alcoholytic activity
-
-
?
additional information
?
-
the product of the TM0913 gene, has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities
-
-
?
additional information
?
-
-
the product of the TM0913 gene, has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities
-
-
?
additional information
?
-
the product of the TM0913 gene, has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities
-
-
?
additional information
?
-
the structural requirements and the conservation of the amino acids of the catalytic site of TaNPPr and, by extension, probably of all NPPs, are very stringent
-
-
?
additional information
?
-
-
the structural requirements and the conservation of the amino acids of the catalytic site of TaNPPr and, by extension, probably of all NPPs, are very stringent
-
-
?
additional information
?
-
-
hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview
-
-
?
additional information
?
-
-
hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview
-
-
?
