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3.6.1.9: nucleotide diphosphatase

This is an abbreviated version!
For detailed information about nucleotide diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.9

Reaction

a nucleoside triphosphate
+
H2O
=
A nucleotide
 +
diphosphate

Synonyms

ADPglucose pyrophosphatase/phosphodiesterase, AGPPase, AGPPase1, AGPPase2, alkaline sphingomyelinase nucleotide pyrophosphatase phosphodiesterase 7, Apyrase, ASMTL-Maf, BSU28050, CBS-PPase, CBS-pyrophosphatase, CD203c, CD39, diphosphopyridine nucleotide pyrophosphatase, dITP pyrophosphatase, dITPase, E-NPP, E-NPP1, E-NPP3, E-NTPDase, E-type ATPDase, EC 3.6.1.19, ecto-ATP-diphosphohydrolase, ecto-ATPDase, ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleoside triphosphate diphosphohydrolase 2, ecto-nucleotide phosphodiesterase/pyrophosphatase 6 eNPP6, ecto-nucleotide pyrophosphatase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-nucleotide pyrophosphatase/phosphodiesterase I-3, ecto-nucleotide pyrophosphatase/phosphodiesterase1, ecto-nucleotide pyrophosphatase/phosphodiesterase3, ecto-nucleotide pyrophosphatase/phosphodiesterases, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase family member 3, ENPP1, ENPP3, ENTPD1, Entpd6, family II pyrophosphatase, h-NPP-1, h-NPP-3, h-NPP1, h-NPP3, HAM1, inosine triphosphatase, inosine triphosphate pyrophosphatase, inosine triphosphate pyrophosphohydrolase, ITPA, ITPase, Maf protein, Maf-like protein YhdE, MazG, MazG protein, MazG-related protein, More, MutT, NPP, NPP 1, NPP 2, NPP 3, NPP-5, NPP1, NPP2, NPP3, NPP6, NPP7, NPPase, NPPr, NTPDase, nucleoside triphosphate diphosphatase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate pyrophosphatase, nucleoside triphosphate pyrophosphohydrolase, nucleoside-triphosphate pyrophosphatase, nucleotide pyrophosphastases/phosphodiesterases1, nucleotide pyrophosphastases/phosphodiesterases3, nucleotide pyrophosphatase, nucleotide pyrophosphatase-1, nucleotide pyrophosphatase-3, nucleotide pyrophosphatase-5, nucleotide pyrophosphatase/phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase NPP1, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-I, nucleotide pyrophosphatase/phosphodiesterases, nucleotide pyrophosphohydrolase, nucleotide-sugar pyrophosphatase, nucleotide-sugar pyrophosphatase/phosphodiesterase, ONPP, PC-1, plasma cell membrane glycoprotein-1, PPase, pyrophosphatase, nucleoside triphosphate, RdgB, RS21-C6, SAGPPase1, SAGPPase2, Tm-MazG, TM0159, TM0913, YhdE, YJR069C, YOR111W, ZmNPP1, ZmNPP2, ZmNPP3

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.9 nucleotide diphosphatase

Temperature Stability

Temperature Stability on EC 3.6.1.9 - nucleotide diphosphatase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100
-
no activity after 2 min
40
-
below no thermal inactivation within 60 min
41
-
denaturation above
45
-
rapid loss of activity for the dimeric form, tetrameric form remains fully stable
50
-
heat treatment required for maximal activation, no activity from crude extracts without heat treatment
65
-
half-life: 6.4-10.4 min
70
purified enzyme, pH 8.7, 30 min, stable, 75% activity remaining after 90 min
80
purified enzyme, pH 8.7, half-life is 5 min