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3.6.1.9: nucleotide diphosphatase

This is an abbreviated version!
For detailed information about nucleotide diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.9

Reaction

a nucleoside triphosphate
+
H2O
=
A nucleotide
 +
diphosphate

Synonyms

ADPglucose pyrophosphatase/phosphodiesterase, AGPPase, AGPPase1, AGPPase2, alkaline sphingomyelinase nucleotide pyrophosphatase phosphodiesterase 7, Apyrase, ASMTL-Maf, BSU28050, CBS-PPase, CBS-pyrophosphatase, CD203c, CD39, diphosphopyridine nucleotide pyrophosphatase, dITP pyrophosphatase, dITPase, E-NPP, E-NPP1, E-NPP3, E-NTPDase, E-type ATPDase, EC 3.6.1.19, ecto-ATP-diphosphohydrolase, ecto-ATPDase, ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleoside triphosphate diphosphohydrolase 2, ecto-nucleotide phosphodiesterase/pyrophosphatase 6 eNPP6, ecto-nucleotide pyrophosphatase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-nucleotide pyrophosphatase/phosphodiesterase I-3, ecto-nucleotide pyrophosphatase/phosphodiesterase1, ecto-nucleotide pyrophosphatase/phosphodiesterase3, ecto-nucleotide pyrophosphatase/phosphodiesterases, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase family member 3, ENPP1, ENPP3, ENTPD1, Entpd6, family II pyrophosphatase, h-NPP-1, h-NPP-3, h-NPP1, h-NPP3, HAM1, inosine triphosphatase, inosine triphosphate pyrophosphatase, inosine triphosphate pyrophosphohydrolase, ITPA, ITPase, Maf protein, Maf-like protein YhdE, MazG, MazG protein, MazG-related protein, More, MutT, NPP, NPP 1, NPP 2, NPP 3, NPP-5, NPP1, NPP2, NPP3, NPP6, NPP7, NPPase, NPPr, NTPDase, nucleoside triphosphate diphosphatase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate pyrophosphatase, nucleoside triphosphate pyrophosphohydrolase, nucleoside-triphosphate pyrophosphatase, nucleotide pyrophosphastases/phosphodiesterases1, nucleotide pyrophosphastases/phosphodiesterases3, nucleotide pyrophosphatase, nucleotide pyrophosphatase-1, nucleotide pyrophosphatase-3, nucleotide pyrophosphatase-5, nucleotide pyrophosphatase/phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase NPP1, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-I, nucleotide pyrophosphatase/phosphodiesterases, nucleotide pyrophosphohydrolase, nucleotide-sugar pyrophosphatase, nucleotide-sugar pyrophosphatase/phosphodiesterase, ONPP, PC-1, plasma cell membrane glycoprotein-1, PPase, pyrophosphatase, nucleoside triphosphate, RdgB, RS21-C6, SAGPPase1, SAGPPase2, Tm-MazG, TM0159, TM0913, YhdE, YJR069C, YOR111W, ZmNPP1, ZmNPP2, ZmNPP3

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.9 nucleotide diphosphatase

KI Value

KI Value on EC 3.6.1.9 - nucleotide diphosphatase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.01
(2E)-2-([3-methoxy-4-[(1H-tetrazol-5-yl)methoxy]phenyl]methylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2E)-2-benzylidene[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2E)-2-[(2-oxo-1,2-dihydroquinolin-3-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2E)-2-[(naphthalen-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.00856
(2E)-2-[[2,4-bis(4-methylpiperidin-1-yl)-5-nitrophenyl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.01
(2Z)-2-benzylidene[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-ethylidene[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(2E)-3-phenylprop-2-en-1-ylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(3-phenoxyphenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(4-chlorophenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(4-iodophenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(4-methylphenyl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.00061
(2Z)-2-[(5-bromofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.000467
(2Z)-2-[(5-iodofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.00211
(2Z)-2-[(5-methylfuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.00107
(2Z)-2-[(5-nitrofuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(5-phenylfuran-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.000981
(2Z)-2-[(furan-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(pyridin-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[(thiophen-2-yl)methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[[3-(benzyloxy)phenyl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.00891
(2Z)-2-[[4-(morpholin-4-yl)phenyl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.00421
(2Z)-2-[[5-(dimethylamino)furan-2-yl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
pH 9.0, 37°C, NPP1
0.01
(2Z)-2-[[5-(phenylsulfanyl)furan-2-yl]methylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
above, pH 9.0, 37°C, NPP1
0.00052
1-amino-4-[4-[(4-anilino-6-chloro-1,3,5-triazin-2-yl)amino]-3-sulfoanilino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
versus ATP, pH 9.0, 37°C, NPP1
0.01
1-[(4-methoxyphenyl)methyl]-1H-benzimidazole
above, pH 9.0, 37°C, NPP1
0.00218 - 0.0354
2-MeSADP
0.00447 - 0.0399
2-MeSATP
0.05
3,3'-[(2-chlorophenyl)methylene]bis(4-hydroxy-3,4-dihydro-2H-1-benzopyran-2-one)
versus p-nitrophenyl phenyl phosphate, pH 9.0, 37°C, NPP1
0.0005
5'-O-(boranyl[[hydroxy(phosphonomethyl)phosphoryl]oxy]phosphoryl)adenosine
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
0.012
5'-O-[([[dibromo(phosphono)methyl](hydroxy)phosphoryl]oxy)(hydroxy)phosphoryl]-N,N-diethyladenosine
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
0.15
5,5'-(propane-1,3-diyl)di(1,3,4-oxadiazole-2(3H)-thione)
versus p-nitrophenyl phenyl phosphate, pH 9.0, 37°C, NPP1
0.00026
8,8'-[carbonylbis[azanediyl-3,1-phenylenecarbonylazanediyl(4-methyl-3,1-phenylene)carbonylazanediyl]]di(naphthalene-1,3,5-trisulfonic acid)
versus ATP, pH 9.0, 37°C, NPP1
0.0000013
acidic fibroblast growth factor
-
potent inhibition at nearly stoichiometric concentrations
-
2.7
adenosine
-
competitive inhibition
1
adenosine 3'-monophosphate
-
-
0.00002
adenosine 5'-alpha,beta-methylene-gamma-thiotriphosphate
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
0.052
adenosine 5'-sulfate
-
-
0.036
adenylic acid
-
competitive inhibition
0.00128 - 0.0243
alpha,beta-metADP
0.0022 - 0.0269
alpha,beta-metATP
25
alpha,beta-methylene adenosine 5'-triphosphate
-
-
0.0005 - 0.056
alpha-borano-beta,gamma-MetATP
pH and temperature not specified in the publication, membrane enzyme, versus 4-nitrophenyl-5'-thymidine monophosphate
0.00296 - 0.0205
benzoyl-ATP
0.1
beta,gamma-methyleneadenosine 5'-triphosphate
-
competitive inhibition of formycin 5'-triphosphate hydrolysis
1.5
Cu2+
-
-
0.0085
cytidine 5'-diphosphate
-
competitive inhibition
0.009
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
0.051
di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-gamma,delta-methylene-tetraphosphate
with NPP1, pH 7.3, 37°C
0.02
diadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano
with NPP1, pH 7.3, 37°C
0.00342 - 0.00562
dialADP
0.00409 - 0.0098
dialATP
2.3
dithiothreitol
-
-
0.2
EDTA
-
-
1 - 2
FAD+
Ovis aries aries
-
-
0.002 - 0.0045
gamma-S-adenosine 5'-(alpha,beta-methylene)triphosphate
pH and temperature not specified in the publication, membrane enzyme
0.0025
GDP
-
competitive inhibition
0.00534
N-(3,4-dimethoxyphenyl)-2-[(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]acetamide
versus ATP, pH 9.0, 37°C, NPP1
0.000059
N-[2-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
0.408
N1-butylnicotinamide chloride
-
competitive inhibition
0.48
N1-heptylnicotinamide chloride
-
competitive inhibition
0.629
N1-hexylnicotinamide chloride
-
competitive inhibition
0.287
N1-octylnicotinamide chloride
-
competitive inhibition
0.297
N1-pentylnicotinamide chloride
-
competitive inhibition
2
Ni2+
-
-
0.013
P1,P4-bis(5'-adenosyl)-alpha,beta-gamma,delta-bismethylene-tetraphosphate
with NPP1, pH 7.3, 37°C
4
phosphate
-
-
0.000005
polyoxymetalate PSB-POM141
versus 4-nitrophenyl 5'-thymidine monophosphate, pH 9.0, 37°C, NPP1
-
0.00052 - 0.00071
Reactive blue 2
0.00004 - 0.00026
suramin
29
UDP-galactose
-
competitive inhibition
0.0012
uridine 5'-diphosphate
-
competitive inhibition
20
Zn2+
-
-
additional information
additional information
-