3.6.1.9: nucleotide diphosphatase
This is an abbreviated version!
For detailed information about nucleotide diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.9
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3.6.1.9
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ecosystem
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climate
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forest
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accident
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basophil
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chernobyl
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terrestrial
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land
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atmospheric
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phosphorus
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grassland
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aboveground
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fukushima
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allergy
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ribavirin
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radionuclides
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phytase
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thiopurine
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tibia
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belowground
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ash
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canopy
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budget
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boreal
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biome
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rbv
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anti-ige
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modis
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interannual
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meteorological
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disaster
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arid
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azathioprine
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ukraine
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hydrological
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rainfall
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corn-soybean
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coniferous
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ectonucleotidases
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peg-ifn
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ntpdases
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earthquake
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croplands
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ecto-nucleoside
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diphosphohydrolase
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year-1
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land-use
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mercaptopurine
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e-ntpdase
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steppe
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medicine
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drug development
- 3.6.1.9
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ecosystem
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climate
-
forest
- accident
-
basophil
-
chernobyl
-
terrestrial
-
land
-
atmospheric
- phosphorus
-
grassland
-
aboveground
-
fukushima
- allergy
- ribavirin
-
radionuclides
- phytase
- thiopurine
-
tibia
-
belowground
- ash
-
canopy
-
budget
-
boreal
-
biome
- rbv
-
anti-ige
-
modis
-
interannual
-
meteorological
-
disaster
-
arid
- azathioprine
-
ukraine
-
hydrological
-
rainfall
-
corn-soybean
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coniferous
- ectonucleotidases
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peg-ifn
- ntpdases
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earthquake
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croplands
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ecto-nucleoside
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diphosphohydrolase
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year-1
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land-use
- mercaptopurine
- e-ntpdase
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steppe
- medicine
- drug development
Reaction
Synonyms
ADPglucose pyrophosphatase/phosphodiesterase, AGPPase, AGPPase1, AGPPase2, alkaline sphingomyelinase nucleotide pyrophosphatase phosphodiesterase 7, Apyrase, ASMTL-Maf, BSU28050, CBS-PPase, CBS-pyrophosphatase, CD203c, CD39, diphosphopyridine nucleotide pyrophosphatase, dITP pyrophosphatase, dITPase, E-NPP, E-NPP1, E-NPP3, E-NTPDase, E-type ATPDase, EC 3.6.1.19, ecto-ATP-diphosphohydrolase, ecto-ATPDase, ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleoside triphosphate diphosphohydrolase 2, ecto-nucleotide phosphodiesterase/pyrophosphatase 6 eNPP6, ecto-nucleotide pyrophosphatase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-nucleotide pyrophosphatase/phosphodiesterase I-3, ecto-nucleotide pyrophosphatase/phosphodiesterase1, ecto-nucleotide pyrophosphatase/phosphodiesterase3, ecto-nucleotide pyrophosphatase/phosphodiesterases, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase family member 3, ENPP1, ENPP3, ENTPD1, Entpd6, family II pyrophosphatase, h-NPP-1, h-NPP-3, h-NPP1, h-NPP3, HAM1, inosine triphosphatase, inosine triphosphate pyrophosphatase, inosine triphosphate pyrophosphohydrolase, ITPA, ITPase, Maf protein, Maf-like protein YhdE, MazG, MazG protein, MazG-related protein, More, MutT, NPP, NPP 1, NPP 2, NPP 3, NPP-5, NPP1, NPP2, NPP3, NPP6, NPP7, NPPase, NPPr, NTPDase, nucleoside triphosphate diphosphatase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate pyrophosphatase, nucleoside triphosphate pyrophosphohydrolase, nucleoside-triphosphate pyrophosphatase, nucleotide pyrophosphastases/phosphodiesterases1, nucleotide pyrophosphastases/phosphodiesterases3, nucleotide pyrophosphatase, nucleotide pyrophosphatase-1, nucleotide pyrophosphatase-3, nucleotide pyrophosphatase-5, nucleotide pyrophosphatase/phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase NPP1, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-I, nucleotide pyrophosphatase/phosphodiesterases, nucleotide pyrophosphohydrolase, nucleotide-sugar pyrophosphatase, nucleotide-sugar pyrophosphatase/phosphodiesterase, ONPP, PC-1, plasma cell membrane glycoprotein-1, PPase, pyrophosphatase, nucleoside triphosphate, RdgB, RS21-C6, SAGPPase1, SAGPPase2, Tm-MazG, TM0159, TM0913, YhdE, YJR069C, YOR111W, ZmNPP1, ZmNPP2, ZmNPP3
ECTree
3.6.1.9 nucleotide diphosphataseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.6.1.9 - nucleotide diphosphatase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3 diadenosine 5',5''-P1,P4-tetraphosphate + 3 H2O
2 ATP + 2 ADP + 2 AMP
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-
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?
4-nitrophenyl-5'-TMP + H2O
4-nitrophenol + 5'-TMP
hydrolysis of pnp-TMP at the cell surface of both osteocarcinoma and colon cancer cells
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-
?
diadenosine 5',5''-P1,P5-pentaposphate + H2O
ATP + ADP + AMP + adenosine 5'-tetraphosphate
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-
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?
UDP-N-acetyl-alpha-D-galactosamine + H2O
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP
2',3'-cAMP + H2O
adenosine monophosphate
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low activity for the tetramer
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?
ATP + H2O
AMP + diphosphate
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ADP formation as a result of adenylate kinase activity
?
ATP + H2O
AMP + diphosphate
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accounts for 50-75% of extracellular hydrolysed ATP
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?
ATP + H2O
AMP + diphosphate
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extracellular ATP mainly hydrolysed by ecto-nucleotide pyrophosphatase, enzyme modulates purinoceptor-mediated signal transduction
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?
mRNA + H2O
7-methyl-GMP + ?
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reovirus m7-G(5')p3(5')Gm-terminated intact mRNA
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?
NADH + H2O
NMNH + AMP
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reduced and oxidized forms, split by two different pyrophosphatase in the crude extract, oxidized form not split by the purified enzyme
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?
NADH + H2O
NMNH + AMP
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alpha-isomer, reduced activity for both reduced and oxidized forms
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?
NADH + H2O
NMNH + AMP
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best natural substrate, reduced form more rapidly hydrolysed than oxidized form
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?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
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only reduced form hydrolysed
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?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
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-
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?
NADP+ + H2O
nicotinamide nucleotide + adenosine 2',5'-bisphosphate
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-
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?
NADPH + H2O
NMNH + adenosine 2',5'-phosphate
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reduced form more rapidly hydrolysed than oxidized form
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?
UDP-glucose + H2O
UMP + D-glucose-1-phosphate
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best substrate of nucleotide-sugars tested
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?
UDP-glucuronic acid + H2O
UMP + glucuronic acid phosphate
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-
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?
UDP-N-acetyl-alpha-D-galactosamine + H2O
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP
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-
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?
UDP-N-acetyl-alpha-D-galactosamine + H2O
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP
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-
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?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
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-
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?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
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-
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?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
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-
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?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
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-
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?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
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-
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?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
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-
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?
UDP-N-acetyl-alpha-D-glucosamine + H2O
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
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-
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?
additional information
?
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hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview
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-
?
additional information
?
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E-NPP3 is associated with carcinogenesis of human colon cancer
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-
?
additional information
?
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functional enzyme is required in carminerin-deficiency to suppress the resulting pathological endochondral ossifications
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-
?
additional information
?
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the enzyme is an oligomannosidic glycoprotein that may participate in neural cell communication
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-
?
additional information
?
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hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview
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-
?
additional information
?
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hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview
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-
?
