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Literature summary for 3.6.1.9 extracted from

  • Grobben, B.; Claes, P.; Roymans, D.; Esmans, E.L.; Van Onckelen, H.; Slegers, H.
    Ecto-nucleotide pyrophosphatase modulates the purinoceptor-mediated signal transduction and is inhibited by purinoceptor antagonists (2000), Br. J. Pharmacol., 130, 139-145.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.9

Inhibitors

Inhibitors Comment Organism Structure
4,4'-diisothiocyanatostilbene-2,2' disulfonic acid P2-purinoceptor antagonist, less potent inhibition, IC50: 0.022 mM Rattus sp.
5'-phosphoadenosine 3'-phosphate P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.036 mM Rattus sp.
pyridoxal phosphate-6-azophenyl-2',4'disulfonic acid P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM Rattus sp.
Reactive blue 2 P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM Rattus sp.
suramin P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.072 mM Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Rattus sp. 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Rattus sp. extracellular ATP mainly hydrolysed by ecto-nucleotide pyrophosphatase, enzyme modulates purinoceptor-mediated signal transduction AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell
-
 Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O extracellular ATP mainly hydrolysed by ecto-nucleotide pyrophosphatase, enzyme modulates purinoceptor-mediated signal transduction Rattus sp. AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
ecto-nucleotide pyrophosphatase
-
 Rattus sp.

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.012
-
 P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM Rattus sp. Reactive blue 2
0.012
-
 P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM Rattus sp. pyridoxal phosphate-6-azophenyl-2',4'disulfonic acid
0.022
-
 P2-purinoceptor antagonist, less potent inhibition, IC50: 0.022 mM Rattus sp. 4,4'-diisothiocyanatostilbene-2,2' disulfonic acid
0.036
-
 P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.036 mM Rattus sp. 5'-phosphoadenosine 3'-phosphate
0.072
-
 P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.072 mM Rattus sp. suramin