Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | the mammalian members of the NPP1-3 family are type II (intracellular N-terminus) transmembrane glycoproteins | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14638 | - |
- |
Homo sapiens | P22413 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | NPP1 is highly expressed in bone, in bone tissue, NPP1 activity is mainly associated with osteoblast- and chondrocyte-derived membrane structures termed matrix vesicles, where it has been identified as the key diphosphate-generating enzyme ensuring normal bone matrix mineralization and soft tissue calcification | Homo sapiens | - |
cartilage | NPP1 is highly expressed in cartilage | Homo sapiens | - |
heart | intermediate NPP1 enzyme expression | Homo sapiens | - |
kidney | intermediate NPP1 enzyme expression | Homo sapiens | - |
liver | intermediate NPP1 enzyme expression | Homo sapiens | - |
placenta | intermediate NPP1 enzyme expression | Homo sapiens | - |
testis | intermediate NPP1 enzyme expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Homo sapiens | AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
E-NPP | - |
Homo sapiens |
ecto-nucleotide pyrophosphatase/phosphodiesterase | - |
Homo sapiens |
NPP1 | isoform, previous name plasma cell differentiation antigen-1, PC-1 | Homo sapiens |
NPP3 | isoform, also named gp130RB13-6,B10,phosphodiesterase 1beta | Homo sapiens |