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Literature summary for 3.6.1.9 extracted from

  • Yegutkin, G.G.
    Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade (2008), Biochim. Biophys. Acta, 1783, 673-694.
    View publication on PubMed
Search for more literature for 3.6.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the mammalian members of the NPP1-3 family are type II (intracellular N-terminus) transmembrane glycoproteins Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O14638
-
-
Homo sapiens P22413
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
bone NPP1 is highly expressed in bone, in bone tissue, NPP1 activity is mainly associated with osteoblast- and chondrocyte-derived membrane structures termed matrix vesicles, where it has been identified as the key diphosphate-generating enzyme ensuring normal bone matrix mineralization and soft tissue calcification Homo sapiens
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cartilage NPP1 is highly expressed in cartilage Homo sapiens
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heart intermediate NPP1 enzyme expression Homo sapiens
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kidney intermediate NPP1 enzyme expression Homo sapiens
-
liver intermediate NPP1 enzyme expression Homo sapiens
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placenta intermediate NPP1 enzyme expression Homo sapiens
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testis intermediate NPP1 enzyme expression Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Homo sapiens AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
E-NPP
-
 Homo sapiens
ecto-nucleotide pyrophosphatase/phosphodiesterase
-
 Homo sapiens
NPP1 isoform, previous name plasma cell differentiation antigen-1, PC-1 Homo sapiens
NPP3 isoform, also named gp130RB13-6,B10,phosphodiesterase 1beta Homo sapiens