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Literature summary for 3.6.1.9 extracted from
- Vicia villosa B4 lectin inhibits nucleotide pyrophosphatase activity toward UDP-GalNAc specifically (1998), Biochim. Biophys. Acta, 1425, 215-223.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| B4 lectin | from Vicia villosa, strong inhibition between 0.002-0.02 mM, specific for hydrolysis of UDP-N-acetyl-alpha-D-galactosamine, reversal by addition of N-acetyl-alpha-D-galactosamine, only weakly inhibitory towards UDP-galactose or UDP-GlcNAc | Bos taurus | |
| lectin | from Wistaria floribunda, inhibition for hydrolysis of UDP-N-acetyl-alpha-D-galactosamine, reversal by addition of N-acetyl-alpha-D-galactosamine | Bos taurus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | 0.05 | UDP-N-acetyl-alpha-D-galactosamine | in the presence of B4 lectin from Vicia villosa | Bos taurus |  |
| 0.067 | - |
UDP-N-acetyl-alpha-D-galactosamine | - |
Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-galactose + H2O | Bos taurus | - |
UMP + alpha-D-galactose-1-phosphate | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + H2O | Bos taurus | - |
N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP | - |
? | |
| UDP-N-acetyl-alpha-D-glucosamine + H2O | Bos taurus | - |
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
phosphodiesterase I, EC 3.1.4.1 | - |
| Crotalus adamanteus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Bos taurus |
| glycoprotein | - |
Crotalus adamanteus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Bos taurus | - |
| venom | - |
Crotalus adamanteus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-galactose + H2O | - |
Bos taurus | UMP + alpha-D-galactose-1-phosphate | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + H2O | - |
Bos taurus | N-acetyl-alpha-D-galactosaminyl-1-phosphate + UMP | - |
? | |
| UDP-N-acetyl-alpha-D-glucosamine + H2O | - |
Bos taurus | UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| nucleotide pyrophosphatase/phosphodiesterase-I | - |
Bos taurus |
| nucleotide pyrophosphatase/phosphodiesterase-I | - |
Crotalus adamanteus |
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