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3.6.1.9: nucleotide diphosphatase

This is an abbreviated version!
For detailed information about nucleotide diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.9

Reaction

a nucleoside triphosphate
+
H2O
=
A nucleotide
 +
diphosphate

Synonyms

ADPglucose pyrophosphatase/phosphodiesterase, AGPPase, AGPPase1, AGPPase2, alkaline sphingomyelinase nucleotide pyrophosphatase phosphodiesterase 7, Apyrase, ASMTL-Maf, BSU28050, CBS-PPase, CBS-pyrophosphatase, CD203c, CD39, diphosphopyridine nucleotide pyrophosphatase, dITP pyrophosphatase, dITPase, E-NPP, E-NPP1, E-NPP3, E-NTPDase, E-type ATPDase, EC 3.6.1.19, ecto-ATP-diphosphohydrolase, ecto-ATPDase, ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleoside triphosphate diphosphohydrolase 2, ecto-nucleotide phosphodiesterase/pyrophosphatase 6 eNPP6, ecto-nucleotide pyrophosphatase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-nucleotide pyrophosphatase/phosphodiesterase I-3, ecto-nucleotide pyrophosphatase/phosphodiesterase1, ecto-nucleotide pyrophosphatase/phosphodiesterase3, ecto-nucleotide pyrophosphatase/phosphodiesterases, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase family member 3, ENPP1, ENPP3, ENTPD1, Entpd6, family II pyrophosphatase, h-NPP-1, h-NPP-3, h-NPP1, h-NPP3, HAM1, inosine triphosphatase, inosine triphosphate pyrophosphatase, inosine triphosphate pyrophosphohydrolase, ITPA, ITPase, Maf protein, Maf-like protein YhdE, MazG, MazG protein, MazG-related protein, More, MutT, NPP, NPP 1, NPP 2, NPP 3, NPP-5, NPP1, NPP2, NPP3, NPP6, NPP7, NPPase, NPPr, NTPDase, nucleoside triphosphate diphosphatase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate pyrophosphatase, nucleoside triphosphate pyrophosphohydrolase, nucleoside-triphosphate pyrophosphatase, nucleotide pyrophosphastases/phosphodiesterases1, nucleotide pyrophosphastases/phosphodiesterases3, nucleotide pyrophosphatase, nucleotide pyrophosphatase-1, nucleotide pyrophosphatase-3, nucleotide pyrophosphatase-5, nucleotide pyrophosphatase/phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase NPP1, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-I, nucleotide pyrophosphatase/phosphodiesterases, nucleotide pyrophosphohydrolase, nucleotide-sugar pyrophosphatase, nucleotide-sugar pyrophosphatase/phosphodiesterase, ONPP, PC-1, plasma cell membrane glycoprotein-1, PPase, pyrophosphatase, nucleoside triphosphate, RdgB, RS21-C6, SAGPPase1, SAGPPase2, Tm-MazG, TM0159, TM0913, YhdE, YJR069C, YOR111W, ZmNPP1, ZmNPP2, ZmNPP3

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.9 nucleotide diphosphatase

KM Value

KM Value on EC 3.6.1.9 - nucleotide diphosphatase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.011
1,4-dihydronicotinamide adenine dinucleotide
-
-
0.0326
2',3''-cGAMP
pH and temperature not specified in the publication, soluble enzyme
2.3
2',3'-cAMP
-
-
0.48
3'-5'-ApC
-
-
0.16
3'-phosphoadenosine 5'-phosphosulfate
-
-
0.12
3'-phosphoadenosine-5'-phosphosulfate
pH and temperature not specified in the publication, membrane enzyme
0.006
3-acetylpyridine adenine dinucleotide
-
-
0.632 - 1.29
3-aminopyridine 1,N6-ethenoadenine dinucleotide
0.007 - 0.056
3-Aminopyridine adenine dinucleotide
0.188
4-nitrophenyl-5'-adenosine monophosphate
pH and temperature not specified in the publication, soluble enzyme
0.0618 - 0.222
4-nitrophenyl-5'-thymidine monophosphate
0.027 - 0.1185
4-nitrophenyl-5'-TMP
0.05
5',5'-diadenosine diphosphate
-
-
0.2
5',5'-diadenosine tetraphosphate
-
-
0.05
5',5'-diadenosine triphosphate
-
-
0.1
5'-adenylylimidodiphosphate
-
-
0.1
7-methyl 5'-guanosine 2'-O-methylguanosine triphosphate
-
-
0.5 - 3
adenosine 5'-phosphosulfate
0.011
adenosine diphosphoribose
-
-
0.18 - 4.3
ADP
0.7 - 0.8
ADP-glucose
0.5 - 18.9
ADP-ribose
0.0051 - 0.0495
Ap3A
0.0205
Ap4A
pH and temperature not specified in the publication, soluble enzyme
0.0062 - 78
ATP
21.88
bis(4-nitrophenyl) phosphate
-
in 0.1 M glycine-NaOH, pH 8.9, at 37°C
2.1 - 3
bis(4-nitrophenyl)phosphate
1.3
bis(p-nitrophenylphosphate)
-
-
1.2
bis-p-nitrophenyl phosphate
-
AGPPase2
0.114
cAMP
pH and temperature not specified in the publication, soluble enzyme
1.9
CDP
pH 4.5, 37°C
0.67
CDP-choline
-
-
0.9 - 1.4
CDP-glucose
0.351
coenzyme A
-
does not exhibit negative cooperativity
0.4 - 1.2
CTP
0.5 - 3.2
dATP
1.7
dCTP
pH 8.0, 70°C
1
dGTP
pH 8.0, 70°C
0.5 - 2.2
diphosphate
0.31
dITP
pH 8.5, 37°C
0.09 - 1.5
dTTP
0.005 - 1.8
FAD
0.1
Formycin 5'-triphosphate
-
-
0.9
GDP
pH 4.5, 37°C
0.04 - 1
GDP-mannose
1 - 4.2
GTP
2.2
IDP
pH 4.5, 37°C
0.51
ITP
pH 8.5, 37°C
0.004 - 31.2
NAD+
0.042 - 20
NADH
0.005 - 0.38
NADP+
0.047 - 0.65
NADPH
0.009 - 0.144
nicotinamide 1,N6-ethenoadenine dinucleotide
0.001
nicotinamide guanine dinucleotide
-
-
0.015
nicotinamide hypoxanthine dinucleotide
-
-
0.008
nicotinic acid adenine dinucleotide
-
-
0.106 - 0.85
p-nitrophenyl 5'-thymidine monophosphate
0.21
p-nitrophenyl 5'-TMP
-
-
21
p-nitrophenyl deoxyTMP
-
-
1.2
p-nitrophenylphosphate
-
-
0.003
pyridine adenine dinucleotide
-
-
1.1 - 2.6
TDP
1.8
TDP-glucose
pH 4.5, 37°C
2.9
thymidine 3'-alpha-naphthylphosphate
-
-
2.7
thymidine 3'-diphospho 3'-thymidine
-
-
1.3 - 6.1
thymidine 3'-monophosphate p-nitrophenyl ester
2.5
thymidine 5'-alpha-naphthylphosphate
-
-
1.3
thymidine 5'-diphospho 5'-thymidine
-
-
0.066 - 20
thymidine 5'-monophosphate p-nitrophenyl ester
0.45 - 1.2
UDP
0.62 - 50
UDP-glucose
0.002 - 0.067
UDP-N-acetyl-alpha-D-galactosamine
0.8
UDP-N-acetyl-alpha-D-glucosamine
-
-
0.0566 - 33
UTP
0.57
xanthosine 5'-triphosphate
pH 8.5, 37°C
additional information
additional information
-