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Literature summary for 3.6.1.9 extracted from
- Nucleotide pyrophosphatase (1950), J. Biol. Chem., 182, 763-778.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5'-AMP | 49% inhibition at 40 mM | Solanum tuberosum |  |
| Borate | strong inhibition at pH 8.5, not at pH 7.4 | Solanum tuberosum | |
| diphosphate | strong inhibition at pH 8.5, not at pH 7.4 | Solanum tuberosum | |
| NADH | effective inhibition of DPN splitting | Solanum tuberosum | |
| nicotinamide | 19% inhibition at 100 mM | Solanum tuberosum | |
| NMN | 10% inhibition at 40 mM | Solanum tuberosum | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Solanum tuberosum | - |
AMP + diphosphate | - |
? | |
| FAD + H2O | Solanum tuberosum | - |
FMN + AMP | - |
? | |
| NADH + H2O | Solanum tuberosum | reduced and oxidized forms | NMNH + AMP | - |
? | |
| NADP+ + H2O | Solanum tuberosum | - |
nicotinamide nucleotide + adenosine 2',5'-bisphosphate | - |
? | |
| thiamine diphosphate + H2O | Solanum tuberosum | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Solanum tuberosum | - |
potato | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Solanum tuberosum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| tuber | - |
Solanum tuberosum | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 36.7 | - |
- |
Solanum tuberosum |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0-5°C, remarkably stable within 15 months | Solanum tuberosum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Solanum tuberosum | AMP + diphosphate | - |
? | |
| FAD + H2O | - |
Solanum tuberosum | FMN + AMP | - |
? | |
| NADH + H2O | reduced and oxidized forms | Solanum tuberosum | NMNH + AMP | - |
? | |
| NADP+ + H2O | - |
Solanum tuberosum | nicotinamide nucleotide + adenosine 2',5'-bisphosphate | - |
? | |
| thiamine diphosphate + H2O | - |
Solanum tuberosum | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.5 | - |
Solanum tuberosum |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4 | - |
50% decreased activity | Solanum tuberosum |
| 9 | - |
50% decreased activity | Solanum tuberosum |
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Release 2023.1 (January 2023)
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