Information on EC 4.1.1.17 - ornithine decarboxylase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
4.1.1.17
-
RECOMMENDED NAME
GeneOntology No.
ornithine decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-ornithine = putrescine + CO2
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Arginine and proline metabolism
-
-
Biosynthesis of antibiotics
-
-
Biosynthesis of secondary metabolites
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-
Glutathione metabolism
-
-
Metabolic pathways
-
-
polyamine pathway
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-
putrescine biosynthesis III
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putrescine biosynthesis IV
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superpathway of ornithine degradation
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-
SYSTEMATIC NAME
IUBMB Comments
L-ornithine carboxy-lyase (putrescine-forming)
A pyridoxal-phosphate protein.
CAS REGISTRY NUMBER
COMMENTARY hide
9024-60-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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-
-
Manually annotated by BRENDA team
an endosymbiont-containing trypanosomatid
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain HM1: IMSS
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
Q040G7
UniProt
Manually annotated by BRENDA team
-
Q040G7
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
strain 30a
-
-
Manually annotated by BRENDA team
strain LdBob
-
-
Manually annotated by BRENDA team
a trypanosomatid parasite causing cutaneous leishmaniasis, constitutive enzyme
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
low expression level of enzyme
Swissprot
Manually annotated by BRENDA team
two isozymes encoded by genes speC and speF
-
-
Manually annotated by BRENDA team
Mus musculus K6/ODC
K6/ODC mice
-
-
Manually annotated by BRENDA team
Neosartorya fischeri
-
-
-
Manually annotated by BRENDA team
cv. Wisconsin 38
-
-
Manually annotated by BRENDA team
no activity in Loktanella hongkongensis
-
-
-
Manually annotated by BRENDA team
no activity in Marinovum algicola
-
-
-
Manually annotated by BRENDA team
no activity in Marinovum algicola ATCC 51442
-
-
-
Manually annotated by BRENDA team
no activity in Phaeobacter gallaeciensis BS107
-
-
-
Manually annotated by BRENDA team
no activity in Raoultella ornithinolytica
-
-
-
Manually annotated by BRENDA team
no activity in Thalassobius mediterraneus
-
-
-
Manually annotated by BRENDA team
no activity in Thalassobius mediterraneus XSM19
-
-
-
Manually annotated by BRENDA team
no activity in Thalassococcus halodurans
-
-
-
Manually annotated by BRENDA team
no activity in Thalassococcus halodurans UST050418-052
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-
-
Manually annotated by BRENDA team
Oenococcus oeni IOEB 89006
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UniProt
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
strain Jma
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Manually annotated by BRENDA team
strain T274
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-
Manually annotated by BRENDA team
strain FCR 3TC
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
diverse strains, overview
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
strain IFI65, isolated from a spoiled Spanish dry-cured ham, gene speF
SwissProt
Manually annotated by BRENDA team
strain IFI65, isolated from a spoiled Spanish dry-cured ham, gene speF
SwissProt
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
strain B006, ATCC PTA-7961
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-
Manually annotated by BRENDA team
strain B006, ATCC PTA-7961
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
JC2049
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Manually annotated by BRENDA team
JC2049
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Manually annotated by BRENDA team
a trypanosomatid causing Chagas disease, constitutive enzyme
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-
Manually annotated by BRENDA team
ground squirrel
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5alpha-dihydrotestosterone
?
show the reaction diagram
-
administration of 0.1 mM to the heart elicits a significant increase in ornithine decarboxylase activity in the left atrium of control male rats, that tends to decrease in gonadectomized rats, the effect is significant for female rats. Testosterone plasma levels positively correlate with the gradient of modifications of ornithine decarboxylase activity elicited by 5alpha-dihydrotestosterone exposure
-
-
?
alpha-methylornithine
2-methyl-1-pyrroline + NH3
show the reaction diagram
-
-
-
?
Arg
1-Amino-4-guanidinobutane
show the reaction diagram
-
0.1% of the activity with L-Orn
-
-
-
D-ornithine
putrescine + CO2
show the reaction diagram
-
very weak activity
-
?
L-2,4-diaminobutanoate
1,3-diaminopropane + CO2
show the reaction diagram
L-2,4-Diaminobutyrate
1,3-Diaminopropane + CO2
show the reaction diagram
-
2% of the activity with L-Orn
-
-
-
L-Lys
1,5-diaminopentane + CO2
show the reaction diagram
L-lysine
1,5-diaminopentane + CO2
show the reaction diagram
L-lysine
cadaverine + CO2
show the reaction diagram
L-Orn
?
show the reaction diagram
L-Orn
Putrescine + CO2
show the reaction diagram
L-ornithine
putrescine + CO2
show the reaction diagram
ornithine
putrescine + CO2
show the reaction diagram
-
-
-
-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5alpha-dihydrotestosterone
?
show the reaction diagram
-
administration of 0.1 mM to the heart elicits a significant increase in ornithine decarboxylase activity in the left atrium of control male rats, that tends to decrease in gonadectomized rats, the effect is significant for female rats. Testosterone plasma levels positively correlate with the gradient of modifications of ornithine decarboxylase activity elicited by 5alpha-dihydrotestosterone exposure
-
-
?
L-lysine
1,5-diaminopentane + CO2
show the reaction diagram
Q9FPK5
-
-
?
L-Orn
?
show the reaction diagram
L-ornithine
putrescine + CO2
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(-)-epigallocatechin-3-gallate
-
polyphenolic compound of green tea with putative anti-cancer activity
(2R)-2-amino-4-[(2-oxopropyl)amino]butanoic acid
-
-
(2R)-2-amino-5-[(2-oxopropyl)amino]pentanoic acid
-
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(2S)-5-amino-2-hydrazinylpentanoic acid
-
-
(DL)-difluoromethylornithine
-
irreversible inactivation, 50% inhibition at 0.0075 mM D-difluoromethylornithine
1,3-Diaminopropane
1,4-Diamino-2-butanone
1,4-Dimethylputrescine
-
none of the three isomers, meso, +, and - inhibits in vitro, but strongly inhibits in vivo in rats or in H-35 hepatoma cells
1-amino-oxy-3-aminopropane
1-diethyl-2-hydroxy-2-nitroso-hydrazine
-
nitric oxide donor, inhibition via S-nitrosylation of Cys360 in the active site of ODC
1H-indol-3-yl(morpholin-4-yl)acetonitrile
-
-
2-(difluoromethyl)-L-ornithine
-
ODC suicide inhibitor, 5 mM alpha-difluromethylornithine reduces ODC activity by 45fold
2-(difluoromethyl)ornithine
complete inhibition
-
2-phenylethyl carbamimidothioate
-
-
3-(morpholin-4-ylmethyl)-1H-indole
-
-
4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide
-
-
4-aminobutyrate
-
-
4-chloromercuribenzoate
5,5'-dithiobis(2-nitrobenzoic acid)
5-Aminopentanoate
-
-
5-Hydrazino-ornithine
-
competitive
6-Aminohexanoate
-
-
agmatine
alexidine
-
-
alpha-difluoromethylornithine
alpha-difluoroornithine
-
-
alpha-DL-difluoromethylornithine
alpha-Methylornithine
antizyme
antizyme 1
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ODC is regulated by specific inhibitors, antizymes which in turn are inhibited by antizyme inhibitors. ODC alone is not degraded in reticulocyte lysate, whereas in the presence of antizyme 1, the degradation occurs rapidly. When antizyme inhibitor or ODC paralogue is added to the mixture, the antizyme 1-induced degradation of ODC is prevented.
-
Ba2+
-
0.8 mM, 50% inhibition
benzene-1,3-diyldiethane-2,1-diyl dicarbamimidothioate
-
-
benzene-1,4-diyldimethanediyl dicarbamimidothioate
-
-
but-2-yne-1,4-diyl dicarbamimidothioate
-
-
butane-1,4-diyl dicarbamimidothioate
-
-
Butylamine
-
-
Ca2+
-
0.9 mM, 50% inhibition
cadaverine
Carbamoyl phosphate
-
-
CGP52622A
CGP54619A
-
3-amino-oxy-1-propanamine analog, 0.000025 mM, 50% inhibition of recombinant Pf-Hinge-ODC
-
Co2+
-
0.5 mM, 50% inhibition
CPG541169A
-
0.000025 mM, 50% inhibition
-
D-ornithine
difluoro-methyl-ornithine
-
-
DL-alpha-Difluoromethylarginine
-
reduces ODC activity by 24%
DL-alpha-difluoromethylornithine
-
1.5 mM DL-alpha-difluoromethylornithine is an effective inhibitor of ODC. In the absence of phenanthrene, treatment reduces ODC activity by 52%.
DL-alpha-Monofluoromethylornithine
ethyl[dimethylaminopropyl]carbodiimide
geneticin
-
G418, weak non-competitive inhibition cs. L-ornithine
Hexylamine
-
-
histamine
-
-
Isonicotinic acid hydrazide
-
-
K+
-
220 mM, 50% inhibition
L-2,4-diaminobutyrate
-
-
L-arginine
L-canaline
-
-
L-lysine
-
competitive inhibition
Ly-294002
-
a PI3K inhibitor
methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]-1-methylhistidinate
-
-
methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]histidinate
-
-
methyl N5-(tert-butoxycarbonyl)-N2-{[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl}-L-ornithinate
-
-
metronidazole
-
-
Mg2+
-
15 mM, 50% inhibition
Mn2+
-
1.0 mM, 50% inhibition
monofluoro-methyl-ornithine
-
-
MTA
1 mM, 70% inhibition
N-(4-ethoxy-1,3-benzothiazol-2-yl)-4-methoxybenzamide
-
-
N-(4-ethoxy-1,3-benzothiazol-2-yl)-4-propoxybenzamide
-
-
N-(4-ethoxy-1,3-benzothiazol-2-yl)benzamide
-
-
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-propoxybenzamide
-
-
N-acetylcysteine
-
decreases enzyme activity in lung carcinoma NCI-H82 cells and reduces the cell viability, overview
N-delta-chloroacetyl-L-ornithine
-
-
N-ethylmaleimide
Orn
-
inhibition of Lys decarboxylation
Ornithine decarboxylase antizyme
ornithine decarboxylase antizyme-1
-
-
-
ornithine decarboxylase antizyme-2
-
-
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ornithine decarboxylase antizyme-3
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-
-
ornithine decarboxylase antizyme-t
-
-
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PD-98059
-
a MEK inhibitor
pentane-1,5-diyl dicarbamimidothioate
-
-
peroxynitrite
-
0.1 mM, 50% inhibition, almost complete inhibition above 1 mM, nitration of tyrosine residues
Phenylglyoxal
phosphopyridoxyl-histidine
-
-
phosphopyridoxyl-L-tryptophan methyl ester
-
-
phosphopyridoxyl-phenylalanine
-
-
propane-1,3-diyl dicarbamimidothioate
-
-
putrescine
pyridoxyl-L-phenylalanine methyl ester
-
-
pyridoxyl-L-tryptophan methyl ester
-
-
S-nitrosoglutathione
-
inhibition likely via S-transnitrosation
Salicylaldehyde
spermidine
spermine
testosterone
29% decrease in activity in female mice, more important chnage in female compared to male mice, overview
testosterone propionate
decreases ODC activity by 56% in adrenal gland of castrated male mice, not in female mice
vitamin C
-
decreases enzyme activity in lung carcinoma NCI-H82 cells and reduces the cell viability, overview
Zn2+
-
0.8 mM, 50% inhibition
additional information