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Literature summary for 4.1.1.17 extracted from

  • Chen, Y.; Weeks, R.S.; Burns, M.R.; Boorman, D.W.; Klein-Szanto, A.; OBrien, T.G.
    Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma (2006), Int. J. Cancer, 118, 2344-2349.
    View publication on PubMed

Application

Application Comment Organism
pharmacology the enzyme is a target in the combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor MQT 1426, i.e. D-Lys-spermine, against murine squamous cell carcinoma, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine the enzyme is inhibited in the combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor MQT 1426, i.e. D-Lys-spermine, against squamous cell carcinoma, the apoptotic index of the cells is transiently increased by combination therapy but not by DFMO alone, a K6/ODC mouse model, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Mus musculus
-
putrescine + CO2
-
?
L-ornithine Mus musculus FVB/N
-
putrescine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
K6/ODC mice
-
Mus musculus FVB/N
-
K6/ODC mice
-

Source Tissue

Source Tissue Comment Organism Textmining
squamous cell carcinoma cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Mus musculus putrescine + CO2
-
?
L-ornithine
-
Mus musculus FVB/N putrescine + CO2
-
?

Synonyms

Synonyms Comment Organism
ODC
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Mus musculus