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Literature summary for 4.1.1.17 extracted from

  • Nasizadeh, S.; Thiman, L.; Persson, L.
    Sequence elements essential for the rapid turnover of Crithidia fasciculata ornithine decarboxylase (2008), Amino Acids, 34, 421-428.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and chimeric mutant enzymes in COS cells Crithidia fasciculata
expression of wild-type and chimeric mutant enzymes in COS cells Leishmania donovani

Protein Variants

Protein Variants Comment Organism
additional information construction of chimeric mutant enzymes consisting of sequence from the Crithidia fasciculata and the Leishmania donovani enzymes, e.g. exchanging the C-terminal PEST region, which show altered protein stability compared to the wild-type enzymes, overview Crithidia fasciculata
additional information construction of chimeric mutant enzymes consisting of sequence from the Crithidia fasciculata and the Leishmania donovani enzymes, e.g. exchanging the C-terminal PEST region, which show altered protein stability compared to the wild-type enzymes, overview Leishmania donovani

General Stability

General Stability Organism
Crithidia fasciculata ODC, in contrast to other phylogentically related enzymes, is rapidly degraded also in mammalian systems, and it contains several sequence elements essential for the rapid turnover of the protein, these regions are mainly located in the central part of the enzyme, overview, half-life of the wild-type enzyme is 3.2 h Crithidia fasciculata
Leishmania donovani ODC has a very fast turnover in mammalian cells, but is a stable enzyme, half-life of the wild-type enzyme is 5.5 h Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Crithidia fasciculata Crithidia fasciculata ODC, in contrast to other phylogentically related enzymes, is rapidly degraded also in mammalian systems, and it contains several sequence elements essential for the rapid turnover of the protein, these regions are mainly located in the central part of the enzyme, overview ?
-
?
additional information Leishmania donovani Leishmania donovani ODC has a very fast turnover in mammalian cells, but is a stable enzyme ?
-
?

Organism

Organism UniProt Comment Textmining
Crithidia fasciculata P90517
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Leishmania donovani P27116
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Crithidia fasciculata ODC, in contrast to other phylogentically related enzymes, is rapidly degraded also in mammalian systems, and it contains several sequence elements essential for the rapid turnover of the protein, these regions are mainly located in the central part of the enzyme, overview Crithidia fasciculata ?
-
?
additional information Leishmania donovani ODC has a very fast turnover in mammalian cells, but is a stable enzyme Leishmania donovani ?
-
?

Synonyms

Synonyms Comment Organism
ODC
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Crithidia fasciculata
ODC
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Leishmania donovani

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Crithidia fasciculata
7.5
-
assay at Leishmania donovani