Literature summary for 4.1.1.17 extracted from

Takeuchi, J.; Chen, H.; Hoyt, M.A.; Coffino, P.
Structural elements of the ubiquitin-independent proteasome degron of ornithine decarboxylase (2008), Biochem. J., 410, 401-407.

Search for more literature for 4.1.1.17

Cloned(Commentary)

Cloned (Comment)	Organism
mutated ODC is in vitro transcribed and translated in reticulocyte lysate, expression of His-tagged ODC fused to the human dihydrofolate reductase, DHFR, in Escherichia coli	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
A457W	site-directed mutagenesis, the mutation does not stabilize ODC	Mus musculus
C441A	construction of a duplicated cODC, from fusing ODC to a tandem cODC-cODCC441A at its C-terminus, with the first ODC copy being wild-type including a wild-type Cys441, and the distal C-terminal copy of cODC carrying mutation C441A	Mus musculus
additional information	construction of several truncated enzyme mutants, mutant protein stabilities, overview	Mus musculus
S456A	site-directed mutagenesis, the mutation does not stabilize ODC	Mus musculus

General Stability

General Stability	Organism
mouse ODC is quickly degraded by the 26S proteasome in mammalian and fungal cells	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	mouse ODC is quickly degraded by the 26S proteasome in an ubiquitin-dependent manner in mammalian and fungal cells. Within cODC, Cys441 functions as a proteasome association element, while the C-terminal end of cODC initiates entry into the proteasome	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P00860	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	mouse ODC is quickly degraded by the 26S proteasome in an ubiquitin-dependent manner in mammalian and fungal cells. Within cODC, Cys441 functions as a proteasome association element, while the C-terminal end of cODC initiates entry into the proteasome	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Mus musculus

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Release 2023.1 (January 2023)