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Literature summary for 4.1.1.17 extracted from

  • Jackson, L.K.; Brooks, H.B.; Myers, D.P.; Phillips, M.A.
    Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397 (2003), Biochemistry, 42, 2933-2940.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma brucei

Protein Variants

Protein Variants Comment Organism
F397A 0.6% of wild-type activity Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
L-ornithine
-
Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Trypanosoma brucei
-
putrescine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei P07805
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant ODC Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Trypanosoma brucei putrescine + CO2
-
?

Synonyms

Synonyms Comment Organism
ODC
-
Trypanosoma brucei

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
9.4
-
L-ornithine
-
Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Trypanosoma brucei