Literature summary for 4.1.1.17 extracted from

Giordano, E.; Hillary, R.A.; Vary, T.C.; Pegg, A.E.; Sumner, A.D.; Caldarera, C.M.; Zhang, X.Q.; Song, J.; Wang, J.; Cheung, J.Y.; Shantz, L.M.
Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy (2012), Amino Acids, 42, 507-518.

Search for more literature for 4.1.1.17

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-difluoromethylornithine	suicide inactivator of ODC	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Mus musculus	-
myocyte	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-lysine	L-lysine is a poor substrate for ODC, with a Km approximately 100fold higher than that of L-ornithine	Mus musculus	cadaverine + CO2	-	?
L-ornithine	-	Mus musculus	putrescine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy	Mus musculus

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Release 2023.1 (January 2023)