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Literature summary for 4.1.1.17 extracted from
- Entamoeba histolytica: purification and characterization of ornithine decarboxylase (2002), Exp. Parasitol., 101, 215-222.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,3-diaminopropane | 10 mM, approx. 60% inhibition | Entamoeba histolytica |  |
| 1,4-Diamino-2-butanone | 5 mM, complete inhibition | Entamoeba histolytica | |
| additional information | not inhibited by alpha-difluoromethylornithine | Entamoeba histolytica |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
5 * 45000, SDS-PAGE | Entamoeba histolytica |
| 216000 | - |
gel filtration | Entamoeba histolytica |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | Entamoeba histolytica | involved in polyamine biosynthesis | putrescine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Entamoeba histolytica | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate, DEAE Bio-Gel, Bio-Gel, Affi-Gel 501 | Entamoeba histolytica |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 24.8 | - |
- |
Entamoeba histolytica |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, 2 years, no loss of activity | Entamoeba histolytica |
| 4°C, 1 month, no loss of activity | Entamoeba histolytica |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | - |
Entamoeba histolytica | putrescine + CO2 | - |
? | |
| L-ornithine | involved in polyamine biosynthesis | Entamoeba histolytica | putrescine + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| pentamer | 5 * 45000, SDS-PAGE | Entamoeba histolytica |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ODC | - |
Entamoeba histolytica |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | absolutely required for activity | Entamoeba histolytica | |
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Release 2023.1 (January 2023)
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