Literature summary for 4.1.1.17 extracted from

Hsu, P.C.; Hour, T.C.; Liao, Y.F.; Hung, Y.C.; Liu, C.C.; Chang, W.H.; Kao, M.C.; Tsay, G.J.; Hung, H.C.; Liu, G.Y.
Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2 (2006), Apoptosis, 11, 389-399.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	ODC expression is induced by prolactin through the protein kinase C delta pathway leading to upregulation of Bcl-2 expression and thereby prevention of tumor necrosis factor alpha- and methotrexate-induced apoptosis, rottlerin, a protein kinase C delta inhibitor, completely blocks the induction of ODC activity by prolactin, while alpha-difluoromethylornithine does not, Bcl-2 has no effect on the activity and expression of ODC	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene odc, overexpression in HL-60 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	Bcl-2 has no effect on the activity and expression of ODC	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-ornithine	Homo sapiens	-	putrescine + CO2	-	?
additional information	Homo sapiens	increasing ODC activity is another way of prolactin preventing methotrexate-induced apoptosis, this induction of ODC activity enhances the expression of Bcl-2 strongly enough to bring about the anti-apoptotic function, prolactin-induced ODC activity is not required to upregulate Bcl-2 early, but indispensable in enhancing it later, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene odc	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-ornithine	-	Homo sapiens	putrescine + CO2	-	?
additional information	increasing ODC activity is another way of prolactin preventing methotrexate-induced apoptosis, this induction of ODC activity enhances the expression of Bcl-2 strongly enough to bring about the anti-apoptotic function, prolactin-induced ODC activity is not required to upregulate Bcl-2 early, but indispensable in enhancing it later, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.1	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens

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Release 2023.1 (January 2023)