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Literature summary for 4.1.1.17 extracted from

  • Fonseca, M.S.; Comini, M.A.; Resende, B.V.; Santi, A.M.; Zoboli, A.P.; Moreira, D.S.; Murta, S.M.
    Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony (2017), Exp. Parasitol., 175, 36-43 .
    View publication on PubMed
Search for more literature for 4.1.1.17

Cloned(Commentary)

Cloned (Comment) Organism
gene odc, overexpression in Leishmania guayensis Leishmania guyanensis

Protein Variants

Protein Variants Comment Organism
additional information Leishmania guyanensis odc overexpressor cell lines are generated to investigate the contribution of the gene to the trivalent antimony (SbIII)-resistance phenotype. The ODC-overexpressors parasites present an increase of 2fold in SbIII-resistance index, when compared with the wild-type line. Pharmacological inhibition of ODC with the specific inhibitor alpha-difluoromethylornithine (DFMO) increases the antileishmanial effect of SbIII in all cell lines. Nevertheless the ODC-overexpressor is still more resistant to SbIII than the parental cell line Leishmania guyanensis

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine DFMO, specific inhibitor Leishmania guyanensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Leishmania guyanensis
-
 putrescine + CO2
-
 ?
L-ornithine Leishmania guyanensis BR/1985/M9945
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania guyanensis A0A1E1IR91 i.e. Vianna guyanensis
-
Leishmania guyanensis BR/1985/M9945 A0A1E1IR91 i.e. Vianna guyanensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Leishmania guyanensis putrescine + CO2
-
 ?
L-ornithine
-
 Leishmania guyanensis BR/1985/M9945 putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
BN36_1212510 locus name Leishmania guyanensis
ODC
-
 Leishmania guyanensis

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Leishmania guyanensis

General Information

General Information Comment Organism
physiological function Ornithine decarboxylase (ODC) and gamma-glutamylcysteine synthetase (GSH1) produce molecules that are direct precursors of trypanothione. Trypanosomatids present a unique mechanism for detoxification of peroxides that is dependent on trypanothione (bis-glutathionylspermidine) Leishmania guyanensis