Literature summary for 4.1.1.17 extracted from

Porat, Z.; Landau, G.; Bercovich, Z.; Krutauz, D.; Glickman, M.; Kahana, C.
Yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome: new insights on yeast antizyme (2008), J. Biol. Chem., 283, 4528-4534.

Search for more literature for 4.1.1.17

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cells, co-expression with wild-type mammalian ODC and the yeast/mammlian enzyme chimera	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of yeast antizyme in Saccharomyces cerevisiae results in polyamine depletion and growth inhibition of yeast cells mainly through inhibiting ODC. Overexpression of mammalian antizyme in mammalian cells leads to growth arrest due to polyamine depletion, being an outcome of reduced ODC activity and polyamine uptake. Construction of an ODC mutant lacking the first 47 amino acids and fusion to the C-terminus of mammalian ODC	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
antizyme	yeast, determination of sequences that are important for inhibiting ODC activity and promoting ODC degradation, the yeast ODC is not affected by mammalian antizyme	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Saccharomyces cerevisiae	yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	wild-type strain BY4741	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome, overview	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)