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Literature summary for 4.1.1.17 extracted from

  • Wei, G.; DeFeo, K.; Hayes, C.S.; Woster, P.M.; Mandik-Nayak, L.; Gilmour, S.K.
    Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes (2008), Cancer Res., 68, 2214-2222.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.17

Protein Variants

Protein Variants Comment Organism
additional information construction of ODC-overexpressing K6/ODC transgenic mice in which a keratin 6 promoter directs the expression of ODC to the outer root sheath cells of hair follicles in the skin. Although elevated levels of ODC and polyamines stimulate proliferation of keratinocytes, mutant Ker/ODC cells undergo apoptotic cell death within days of primary culture unlike wild-type Ker/Norm cells that continue to proliferate. Ker/ODC also displays increased generation of H2O2, acroleinlysine conjugates, and protein oxidation products as well as polyamine-dependent DNA damage, phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine specific ODC inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Mus musculus key rate-limiting enzyme in polyamine biosynthesis, elevated levels of ODC and polyamines stimulate proliferation of keratinocytes putrescine + CO2
-
 ?
additional information Mus musculus the enzyme induces phosphorylation of ataxia telangiectasia mutated and its substrate p53, which are significantly induced both in Ker/ODC and in K6/ODC transgenic skin, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Ker/Norm wild-type mice and K6/ODC transgenic mice
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte primary Mus musculus
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skin
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Mus musculus putrescine + CO2
-
 ?
L-ornithine key rate-limiting enzyme in polyamine biosynthesis, elevated levels of ODC and polyamines stimulate proliferation of keratinocytes Mus musculus putrescine + CO2
-
 ?
additional information the enzyme induces phosphorylation of ataxia telangiectasia mutated and its substrate p53, which are significantly induced both in Ker/ODC and in K6/ODC transgenic skin, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ODC
-
 Mus musculus