Reference on EC 3.4.24.B4 - matrix metalloproteinase-13
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
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Equus caballus (O18927), Bos taurus (O77656), Rattus norvegicus (P23097), Xenopus laevis (Q10835)
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Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines
Anticancer Drugs
13
245-254
2002
Homo sapiens
Leeman, M.F.; Curran, S.; Murray, G.I.
The structure, regulation, and function of human matrix metalloproteinase-13
Crit. Rev. Biochem. Mol. Biol.
37
149-166
2002
Homo sapiens
Knaeuper, V.; Lopez-Otin, C.; Smith, B.; Knight, G.; Murphy, G.
Biochemical characterization of human collagenase-3
J. Biol. Chem.
271
1544-1550
1996
Homo sapiens
Knaeuper, V.; Cowell, S.; Smith, B.; Lopez-Otin, C.; O'Shea, M.; Morris, H.; Zardi, L.; Murphy, G.
The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction
J. Biol. Chem.
272
7608-7616
1997
Homo sapiens
Barmina, O.Y.; Walling, H.W.; Fiacco, G.J.; Freije, J.M.; Lopez-Otin, C.; Jeffrey, J.J.; Partridge, N.C.
Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalization
J. Biol. Chem.
274
30087-30093
1999
Rattus norvegicus
Deng, S.J.; Bickett, D.M.; Mitchell, J.L.; Lambert, M.H.; Blackburn, R.K.; Carter, H.L., 3rd; Neugebauer, J.; Pahel, G.; Weiner, M.P.; Moss, M.L.
Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library
J. Biol. Chem.
275
31422-31427
2000
Homo sapiens
Gomis-Rueth, F.X.; Gohlke, U.; Betz, M.; Knauper, V.; Murphy, G.; Lopez-Otin, C.; Bode, W.
The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain
J. Mol. Biol.
264
556-566
1996
Homo sapiens (P45452), Homo sapiens
Botos, I.; Meyer, E.; Swanson, S.M.; Lemaitre, V.; Eeckhout, Y.; Meyer, E.F.
Structure of recombinant mouse collagenase-3 (MMP-13)
J. Mol. Biol.
292
837-844
1999
Mus musculus (P33435), Mus musculus
Zhang, X.; Gonnella, N.C.; Koehn, J.; Pathak, N.; Ganu, V.; Melton, R.; Parker, D.; Hu, S.I.; Nam, K.Y.
Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1
J. Mol. Biol.
301
513-524
2000
Homo sapiens (P45452), Homo sapiens
Moy, F.J.; Chanda, P.K.; Chen, J.M.; Cosmi, S.; Edris, W.; Levin, J.I.; Powers, R.
High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor
J. Mol. Biol.
302
671-689
2000
Homo sapiens (P45452), Homo sapiens
Kohno, T.; Hochigai, H.; Yamashita, E.; Tsukihara, T.; Kanaoka, M.
Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453
Biochem. Biophys. Res. Commun.
344
315-322
2006
Homo sapiens (P45452), Homo sapiens
Bakke, L.J.; Li, Q.; Cassar, C.A.; Dow, M.P.; Pursley, J.R.; Smith, G.W.
Gonadotropin surge-induced differential upregulation of collagenase-1 (MMP-1) and collagenase-3 (MMP-13) mRNA and protein in bovine preovulatory follicles
Biol. Reprod.
71
605-612
2004
Bos taurus
Bikadi, Z.; Hazai, E.; Zsila, F.; Lockwood, S.F.
Molecular modeling of non-covalent binding of homochiral (3S,3S)-astaxanthin to matrix metalloproteinase-13 (MMP-13)
Bioorg. Med. Chem.
14
5451-5458
2006
Homo sapiens (P45452), Homo sapiens
Noe, M.C.; Snow, S.L.; Wolf-Gouveia, L.A.; Mitchell, P.G.; Lopresti-Morrow, L.; Reeves, L.M.; Yocum, S.A.; Liras, J.L.; Vaughn, M.
3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase
Bioorg. Med. Chem. Lett.
14
4727-4730
2004
Homo sapiens
Kim, S.H.; Pudzianowski, A.T.; Leavitt, K.J.; Barbosa, J.; McDonnell, P.A.; Metzler, W.J.; Rankin, B.M.; Liu, R.; Vaccaro, W.; Pitts, W.
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)
Bioorg. Med. Chem. Lett.
15
1101-1106
2005
Homo sapiens
Wu, J.; Rush, T.S.; Hotchandani, R.; Du, X.; Geck, M.; Collins, E.; Xu, Z.B.; Skotnicki, J.; Levin, J.I.; Lovering, F.E.
Identification of potent and selective MMP-13 inhibitors
Bioorg. Med. Chem. Lett.
15
4105-4109
2005
Bos taurus
Reiter, L.A.; Freeman-Cook, K.D.; Jones, C.S.; Martinelli, G.J.; Antipas, A.S.; Berliner, M.A.; Datta, K.; Downs, J.T.; Eskra, J.D.; Forman, M.D.; Greer, E.M.; Guzman, R.; Hardink, J.R.; Janat, F.; Keene, N.F.; Laird, E.R.; Liras, J.L.; Lopresti-Morrow, L.L.; Mitchell, P.G.; Pandit, J.; Robertson, D.; Sperger, D.
Potent, selective pyrimidinetrione-based inhibitors of MMP-13
Bioorg. Med. Chem. Lett.
16
5822-5826
2006
Rattus norvegicus
Nakamura, H.; Sato, G.; Hirata, A.; Yamamoto, T.
Immunolocalization of matrix metalloproteinase-13 on bone surface under osteoclasts in rat tibia
Bone
34
48-56
2004
Rattus norvegicus
Engel, C.K.; Pirard, B.; Schimanski, S.; Kirsch, R.; Habermann, J.; Klingler, O.; Schlotte, V.; Weithmann, K.U.; Wendt, K.U.
Structural basis for the highly selective inhibition of MMP-13
Chem. Biol.
12
181-189
2005
Homo sapiens (P45452)
Sulkala, M.; Paeaekkoenen, V.; Larmas, M.; Salo, T.; Tjaederhane, L.
Matrix metalloproteinase-13 (MMP-13, collagenase-3) is highly expressed in human tooth pulp
Connect. Tissue Res.
45
231-237
2004
Homo sapiens
Calabro, A.; Grappone, C.; Pellegrini, G.; Evangelista, S.; Tramontana, M.; Schuppan, D.; Herbst, H.; Milani, S.
Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing
Digestion
70
127-138
2004
Rattus norvegicus
Nakashima, A.; Tamura, M.
Regulation of matrix metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1 gene expression by WNT3A and bone morphogenetic protein-2 in osteoblastic differentiation
Front. Biosci.
11
1667-1678
2006
Mus musculus
Corte, M.D.; Gonzalez, L.O.; Corte, M.G.; Quintela, I.; Pidal, I.; Bongera, M.; Vizoso, F.
Collagenase-3 (MMP-13) expression in cutaneous malignant melanoma
Int. J. Biol. Markers
20
242-248
2006
Homo sapiens
Zijlstra, A.; Aimes, R.T.; Zhu, D.; Regazzoni, K.; Kupriyanova, T.; Seandel, M.; Deryugina, E.I.; Quigley, J.P.
Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3)
J. Biol. Chem.
279
27633-27645
2004
Gallus gallus
Heathfield, T.F.; Oennerfjord, P.; Dahlberg, L.; Heinegard, D.
Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13
J. Biol. Chem.
279
6286-6295
2004
Bos taurus
Toriseva, M.J.; Ala-Aho, R.; Karvinen, J.; Baker, A.H.; Marjomaeki, V.S.; Heino, J.; Kaehaeri, V.M.
Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts
J. Invest. Dermatol.
127
49-59
2006
Homo sapiens
Kuivanen, T.T.; Jeskanen, L.; Kylloenen, L.; Impola, U.; Saarialho-Kere, U.K.
Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas
Mod. Pathol.
19
1203-1212
2006
Homo sapiens
Inada, M.; Wang, Y.; Byrne, M.H.; Rahman, M.U.; Miyaura, C.; Lopez-Otin, C.; Krane, S.M.
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
Proc. Natl. Acad. Sci. USA
101
17192-17197
2004
Mus musculus
Leonardi, R.; Talic, N.F.; Loreto, C.
MMP-13 (collagenase 3) immunolocalisation during initial orthodontic tooth movement in rats
Acta Histochem.
109
215-220
2007
Rattus norvegicus
Leonardi, R.; Loreto, C.; Barbato, E.; Caltabiano, R.; Lombardo, C.; Musumeci, G.; Muzio, L.L.
MMP-13 (collagenase 3) localization in human temporomandibular joint discs with internal derangement
Acta Histochem.
110
314-318
2008
Homo sapiens
Suri, L.; Damoulis, P.D.; Le, T.; Gagari, E.
Expression of MMP-13 (collagenase-3) in long-term cultures of human dental pulp cells
Arch. Oral Biol.
53
791-799
2008
Homo sapiens
Danfelter, M.; Oennerfjord, P.; Heinegard, D.
Fragmentation of proteins in cartilage treated with interleukin-1: Specific cleavage of type IX collagen by matrix metalloproteinase 13 releases the NC4 domain
J. Biol. Chem.
282
36933-36941
2007
Bos taurus
Fallowfield, J.A.; Mizuno, M.; Kendall, T.J.; Constandinou, C.M.; Benyon, R.C.; Duffield, J.S.; Iredale, J.P.
Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
J. Immunol.
178
5288-5295
2007
Mus musculus
Maskos, K.; Lang, R.; Tschesche, H.; Bode, W.
Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2
J. Mol. Biol.
366
1222-1231
2007
Homo sapiens (P45452), Homo sapiens
Mukhin, Y.V.; Gooz, M.; Raymond, J.R.; Garnovskaya, M.N.
Collagenase-2 and -3 mediate epidermal growth factor receptor transactivation by bradykinin B2 receptor in kidney cells
J. Pharmacol. Exp. Ther.
318
1033-1043
2006
Mus musculus
Leivonen, S.K.; Ala-Aho, R.; Koli, K.; Grenman, R.; Peltonen, J.; Kaehaeri, V.M.
Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells
Oncogene
25
2588-2600
2006
Homo sapiens
Behonick, D.J.; Xing, Z.; Lieu, S.; Buckley, J.M.; Lotz, J.C.; Marcucio, R.S.; Werb, Z.; Miclau, T.; Colnot, C.
Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration
PLoS ONE
2
e1150
2007
Mus musculus
Rodriguez Faba, O.; Fernandez Gomez, J.M.; Palou Redorta, J.; Escaf Barmadah, S.; Vizoso, F.; Villavicencio Mavrich, H.
Significance of collagenase 3 (matrix metalloproteinase 13) in invasive bladder cancer: correlation with pathological parameters
Urol. Int.
78
140-144
2007
Homo sapiens
Zhang, B.; Cao, X.; Liu, Y.; Cao, W.; Zhang, F.; Zhang, S.; Li, H.; Ning, L.; Fu, L.; Niu, Y.; Niu, R.; Sun, B.; Hao, X.
Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer
BMC Cancer
8
83
2008
Homo sapiens
Cuadrado, E.; Rosell, A.; Borrell-Pages, M.; Garcia-Bonilla, L.; Hernandez-Guillamon, M.; Ortega-Aznar, A.; Montaner, J.
Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia
J. Cereb. Blood Flow Metab.
29
398-410
2009
Homo sapiens, Rattus norvegicus
Li, J.J.; Nahra, J.; Johnson, A.R.; Bunker, A.; OBrien, P.; Yue, W.S.; Ortwine, D.F.; Man, C.F.; Baragi, V.; Kilgore, K.; Dyer, R.D.; Han, H.K.
Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
J. Med. Chem.
51
835-841
2008
Rattus norvegicus
Monovich, L.G.; Tommasi, R.A.; Fujimoto, R.A.; Blancuzzi, V.; Clark, K.; Cornell, W.D.; Doti, R.; Doughty, J.; Fang, J.; Farley, D.; Fitt, J.; Ganu, V.; Goldberg, R.; Goldstein, R.; Lavoie, S.; Kulathila, R.; Macchia, W.; Parker, D.T.; Melton, R.; OByrne, E.; Pastor, G.; Pellas, T.; Quadros, E.; Reel, N.
Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13
J. Med. Chem.
52
3523-3538
2009
Homo sapiens, Rattus norvegicus
Sakao, K.; Takahashi, K.A.; Mazda, O.; Arai, Y.; Tonomura, H.; Inoue, A.; Saito, M.; Fujioka, M.; Takamiya, H.; Imanishi, J.; Kubo, T.
Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-kappaB ligand in cells derived from osteoarthritic subchondral bone
J. Orthop. Sci.
13
202-210
2008
Homo sapiens
Ahmad, R.; Sylvester, J.; Ahmad, M.; Zafarullah, M.
Adaptor proteins and Ras synergistically regulate IL-1-induced ADAMTS-4 expression in human chondrocytes
J. Immunol.
182
5081-5087
2009
Homo sapiens (P45452)
Kolodziej, S.A.; Hockerman, S.L.; Boehm, T.L.; Carroll, J.N.; DeCrescenzo, G.A.; McDonald, J.J.; Mischke, D.A.; Munie, G.E.; Fletcher, T.R.; Rico, J.G.; Stehle, N.W.; Swearingen, C.; Becker, D.P.
Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective alpha-sulfone hydroxamates
Bioorg. Med. Chem. Lett.
20
3557-3560
2010
Homo sapiens
Luukkaa, H.; Klemi, P.; Leivo, I.; Maekitie, A.A.; Irish, J.; Gilbert, R.; Perez-Ordonez, B.; Hirsimaeki, P.; Vahlberg, T.; Kivisaari, A.; Kaehaeri, V.M.; Grenman, R.
Expression of matrix metalloproteinase-1, -7, -9, -13, Ki-67, and HER-2 in epithelial-myoepithelial salivary gland cancer
Head Neck
32
1019-1027
2009
Homo sapiens
Tsai, W.C.; Hsu, C.C.; Chang, H.N.; Lin, Y.C.; Lin, M.S.; Pang, J.H.
Ibuprofen upregulates expressions of matrix metalloproteinase-1, -8, -9, and -13 without affecting expressions of types I and III collagen in tendon cells
J. Orthop. Res.
28
487-491
2010
Rattus norvegicus
Ansell, A.; Jerhammar, F.; Ceder, R.; Grafstroem, R.; Grenman, R.; Roberg, K.
Matrix metalloproteinase-7 and -13 expression associate to cisplatin resistance in head and neck cancer cell lines
Oral Oncol.
45
866-871
2009
Homo sapiens
Lausch, E.; Keppler, R.; Hilbert, K.; Cormier-Daire, V.; Nikkel, S.; Nishimura, G.; Unger, S.; Spranger, J.; Superti-Furga, A.; Zabel, B.
Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia
Am. J. Hum. Genet.
85
168-178
2009
Mus musculus, Homo sapiens (P45452), Homo sapiens
Hattori, N.; Mochizuki, S.; Kishi, K.; Nakajima, T.; Takaishi, H.; DArmiento, J.; Okada, Y.
MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing
Am. J. Pathol.
175
533-546
2009
Mus musculus
Fukui, T.; Suga, T.; Iida, R.H.; Morito, M.; Luan, X.; Diekwisch, T.G.; Nakamura, Y.; Yamane, A.
BMP-2 regulates the formation of oral sulcus in mouse tongue by altering the balance between TIMP-1 and MMP-13
Anat. Rec. (Hoboken)
293
1408-1415
2010
Mus musculus
Emingil, G.; Afacan, B.; Tervahartiala, T.; Toez, H.; Atilla, G.; Sorsa, T.
GCF and serum myeloperoxidase and matrix metalloproteinase-13 levels in renal transplant patients
Arch. Oral Biol.
55
719-727
2010
Rattus norvegicus
Choi, H.M.; Lee, Y.A.; Lee, S.H.; Hong, S.J.; Hahm, D.H.; Choi, S.Y.; Yang, H.I.; Yoo, M.C.; Kim, K.S.
Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators
Arthritis Res. Ther.
11
R161
2009
Homo sapiens
Boileau, C.; Martel-Pelletier, J.; Caron, J.; Msika, P.; Guillou, G.B.; Baudouin, C.; Pelletier, J.P.
Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13
Arthritis Res. Ther.
11
R41
2009
Canis lupus familiaris
Rasheed, Z.; Anbazhagan, A.N.; Akhtar, N.; Ramamurthy, S.; Voss, F.R.; Haqqi, T.M.
Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes
Arthritis Res. Ther.
11
R71
2009
Homo sapiens
Baragi, V.M.; Becher, G.; Bendele, A.M.; Biesinger, R.; Bluhm, H.; Boer, J.; Deng, H.; Dodd, R.; Essers, M.; Feuerstein, T. et al.
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models
Arthritis Rheum.
60
2008-2018
2009
Bos taurus, Homo sapiens, Rattus norvegicus
Hayashida, M.; Okazaki, K.; Fukushi, J.; Sakamoto, A.; Iwamoto, Y.
CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis
Arthritis Rheum.
60
708-716
2009
Homo sapiens
Akhtar, N.; Rasheed, Z.; Ramamurthy, S.; Anbazhagan, A.N.; Voss, F.R.; Haqqi, T.M.
MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes
Arthritis Rheum.
62
1361-1371
2010
Homo sapiens
Borzi, R.M.; Olivotto, E.; Pagani, S.; Vitellozzi, R.; Neri, S.; Battistelli, M.; Falcieri, E.; Facchini, A.; Flamigni, F.; Penzo, M.; Platano, D.; Santi, S.; Facchini, A.; Marcu, K.B.
Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors
Arthritis Rheum.
62
2370-2381
2010
Homo sapiens
Settle, S.; Vickery, L.; Nemirovskiy, O.; Vidmar, T.; Bendele, A.; Messing, D.; Ruminski, P.; Schnute, M.; Sunyer, T.
Cartilage degradation biomarkers predict efficacy of a novel highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: Multivariate analysis confirmed that modulation of type II collagen aggrecan degradation peptides paralle
Arthritis Rheum.
62
3006-3015
2010
Canis lupus familiaris, Homo sapiens
Cheng, C.; Tempel, D.; van Haperen, R.; van Damme, L.; Alguer, M.; Krams, R.; de Crom, R.
Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype
Atherosclerosis
204
26-33
2009
Mus musculus
Lu, D.Y.; Leung, Y.M.; Cheung, C.W.; Chen, Y.R.; Wong, K.L.
Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells
Biochem. Pharmacol.
80
1201-1209
2010
Homo sapiens
Achari, Y.; Lu, T.; Katzenellenbogen, B.S.; Hart, D.A.
Distinct roles for AF-1 and -2 of ER-alpha in regulation of MMP-13 promoter activity
Biochim. Biophys. Acta
1792
211-220
2009
Oryctolagus cuniculus
Li, W.; Hu, Y.; Li, J.; Thomason, J.R.; DeVincentis, D.; Du, X.; Wu, J.; Hotchandani, R.; Rush, T.S.; Skotnicki, J.S.; Tam, S.; Chockalingam, P.S.; Morris, E.A.; Levin, J.I.
3,4-Disubstituted benzofuran P1 MMP-13 inhibitors: optimization of selectivity and reduction of protein binding
Bioorg. Med. Chem. Lett.
19
4546-4550
2009
Homo sapiens
Heim-Riether, A.; Taylor, S.J.; Liang, S.; Gao, D.A.; Xiong, Z.; Michael August, E.; Collins, B.K.; Farmer, B.T.; Haverty, K.; Hill-Drzewi, M.; Junker, H.D.; Mariana Margarit, S.; Moss, N.; Neumann, T.; Proudfoot, J.R.; Keenan, L.S.; Sekul, R.; Zhang, Q.; Li, J.; Farrow, N.A.
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors
Bioorg. Med. Chem. Lett.
19
5321-5324
2009
Homo sapiens
Kolodziej, S.A.; Hockerman, S.L.; DeCrescenzo, G.A.; McDonald, J.J.; Mischke, D.A.; Munie, G.E.; Fletcher, T.R.; Stehle, N.; Swearingen, C.; Becker, D.P.
MMP-13 selective isonipecotamide alpha-sulfone hydroxamates
Bioorg. Med. Chem. Lett.
20
3561-3564
2010
Homo sapiens
Gao, D.A.; Xiong, Z.; Heim-Riether, A.; Amodeo, L.; August, E.M.; Cao, X.; Ciccarelli, L.; Collins, B.K.; Harrington, K.; Haverty, K.; Hill-Drzewi, M.; Li, X.; Liang, S.; Margarit, S.M.; Moss, N.; Nagaraja, N.; Proudfoot, J.; Roman, R.; Schlyer, S.; Keenan, L.S.; Taylor, S.; Wellenzohn, B.; Wiedenmayer, D.; Li, J.; Farrow, N.A.
SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability
Bioorg. Med. Chem. Lett.
20
5039-5043
2010
Homo sapiens
Schnute, M.E.; OBrien, P.M.; Nahra, J.; Morris, M.; Howard Roark, W.; Hanau, C.E.; Ruminski, P.G.; Scholten, J.A.; Fletcher, T.R.; Hamper, B.C.; Carroll, J.N.; Patt, W.C.; Shieh, H.S.; Collins, B.; Pavlovsky, A.G.; Palmquist, K.E.; Aston, K.W.; Hitchcock, J.; Rogers, M.D.; McDonald, J.; Johnson, A.R.; Munie, G.E.
Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
Bioorg. Med. Chem. Lett.
20
576-580
2010
Homo sapiens (P45452)
Ziegler, N.; Alonso, A.; Steinberg, T.; Woodnutt, D.; Kohl, A.; Muessig, E.; Schulz, S.; Tomakidi, P.
Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression
BMC Cell Biol.
11
10
2010
Homo sapiens
Tardif, G.; Hum, D.; Pelletier, J.; Duval, N.; Martel-Pelletier, J.
Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
BMC Musculoskelet. Disord.
10
148
2009
Homo sapiens
Mak, I.W.; Cowan, R.W.; Popovic, S.; Colterjohn, N.; Singh, G.; Ghert, M.
Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone
Bone
45
377-386
2009
Homo sapiens (P45452)
Ma, O.; Cai, W.W.; Zender, L.; Dayaram, T.; Shen, J.; Herron, A.J.; Lowe, S.W.; Man, T.K.; Lau, C.C.; Donehower, L.A.
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression
Cancer Res.
69
2559-2567
2009
Homo sapiens, Mus musculus
Nannuru, K.C.; Futakuchi, M.; Varney, M.L.; Vincent, T.M.; Marcusson, E.G.; Singh, R.K.
Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface
Cancer Res.
70
3494-3504
2010
Mus musculus
Tan, T.W.; Yang, W.H.; Lin, Y.T.; Hsu, S.F.; Li, T.M.; Kao, S.T.; Chen, W.C.; Fong, Y.C.; Tang, C.H.
Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells
Carcinogenesis
30
258-268
2009
Homo sapiens
Lederle, W.; Hartenstein, B.; Meides, A.; Kunzelmann, H.; Werb, Z.; Angel, P.; Mueller, M.M.
MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma
Carcinogenesis
31
1175-1184
2010
Mus musculus
Lecomte, J.; Louis, K.; Detry, B.; Blacher, S.; Lambert, V.; Bekaert, S.; Munaut, C.; Paupert, J.; Blaise, P.; Foidart, J.M.; Rakic, J.M.; Krane, S.M.; Noel, A.
Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization
Cell. Mol. Life Sci.
68
677-686
2011
Mus musculus, Homo sapiens (P45452), Homo sapiens, Mus musculus C57BL/6
Jiang, Y.; Abernathy, J.W.; Peatman, E.; Liu, H.; Wang, S.; Xu, D.H.; Kucuktas, H.; Klesius, P.; Liu, Z.
Identification and characterization of matrix metalloproteinase-13 sequence structure and expression during embryogenesis and infection in channel catfish (Ictalurus punctatus)
Dev. Comp. Immunol.
34
590-597
2010
Ictalurus punctatus (E3SW76), Ictalurus punctatus
Varga, F.; Rumpler, M.; Spitzer, S.; Karlic, H.; Klaushofer, K.
Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblasts
Endocr. J.
56
441-450
2009
Mus musculus
Kim, K.S.; Oh, d.a..H.; Choi, H.M.; Bang, J.S.; Ryu, C.J.; Kim, J.H.; Yoo, M.C.; Yang, H.I.
Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes
Eur. J. Pharmacol.
613
167-175
2009
Homo sapiens
Selvamurugan, N.; Shimizu, E.; Lee, M.; Liu, T.; Li, H.; Partridge, N.C.
Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation
FEBS Lett.
583
1141-1146
2009
Rattus norvegicus
Mak, I.W.; Seidlitz, E.P.; Cowan, R.W.; Turcotte, R.E.; Popovic, S.; Wu, W.C.; Singh, G.; Ghert, M.
Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
Hum. Pathol.
41
1320-1329
2010
Homo sapiens, Mus musculus
Kumamoto, K.; Fujita, K.; Kurotani, R.; Saito, M.; Unoki, M.; Hagiwara, N.; Shiga, H.; Bowman, E.D.; Yanaihara, N.; Okamura, S.; Nagashima, M.; Miyamoto, K.; Takenoshita, S.; Yokota, J.; Harris, C.C.
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression
Int. J. Cancer
125
1306-1315
2009
Homo sapiens
Yang, L.; Guo, A.; Gu, J.C.
c-Jun N-terminal kinase and nuclear factor kappaB mediate nitric oxide-induced expression of matrix metalloproteinase-13
Int. Orthop.
35
1261-1266
2011
Homo sapiens
Wargelius, A.; Fjelldal, P.; Grini, A.; Gil-Martens, L.; Kvamme, B.; Hansen, T.
MMP-13 (Matrix MetalloProteinase 13) expression might be an indicator for increased ECM remodeling and early signs of vertebral compression in farmed Atlantic salmon (Salmo salar L.)
J. Appl. Ichthyol.
26
366-371
2010
Salmo salar (B5X4P7)
-
Yang, C.M.; Hsieh, H.L.; Yao, C.C.; Hsiao, L.D.; Tseng, C.P.; Wu, C.B.
Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells
J. Biol. Chem.
284
26040-26050
2009
Mus musculus
Shimizu, E.; Selvamurugan, N.; Westendorf, J.J.; Olson, E.N.; Partridge, N.C.
HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression
J. Biol. Chem.
285
9616-9626
2010
Mus musculus, Rattus norvegicus
Tan, T.W.; Lai, C.H.; Huang, C.Y.; Yang, W.H.; Chen, H.T.; Hsu, H.C.; Fong, Y.C.; Tang, C.H.
CTGF enhances migration and MMP-13 up-regulation via alphanybeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells
J. Cell. Biochem.
107
345-356
2009
Homo sapiens
Lu, D.Y.; Yu, W.H.; Yeh, W.L.; Tang, C.H.; Leung, Y.M.; Wong, K.L.; Chen, Y.F.; Lai, C.H.; Fu, W.M.
Hypoxia-induced matrix metalloproteinase-13 expression in astrocytes enhances permeability of brain endothelial cells
J. Cell. Physiol.
220
163-173
2009
Rattus norvegicus
Hernandez Rios, M.; Sorsa, T.; Obregon, F.; Tervahartiala, T.; Valenzuela, M.A.; Pozo, P.; Dutzan, N.; Lesaffre, E.; Molas, M.; Gamonal, J.
Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade
J. Clin. Periodontol.
36
1011-1017
2009
Homo sapiens
Pirhan, D.; Atilla, G.; Emingil, G.; Tervahartiala, T.; Sorsa, T.; Berdeli, A.
MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy
J. Clin. Periodontol.
36
474-481
2009
Homo sapiens
Hong, H.; Park, Y.K.; Choi, M.S.; Ryu, N.H.; Song, D.K.; Suh, S.I.; Nam, K.Y.; Park, G.Y.; Jang, B.C.
Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride
J. Dermatol. Sci.
56
43-50
2009
Homo sapiens
Blaney Davidson, E.N.; Remst, D.F.; Vitters, E.L.; van Beuningen, H.M.; Blom, A.B.; Goumans, M.J.; van den Berg, W.B.; van der Kraan, P.M.
Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice
J. Immunol.
182
7937-7945
2009
Homo sapiens, Mus musculus
Nuti, E.; Casalini, F.; Avramova, S.I.; Santamaria, S.; Cercignani, G.; Marinelli, L.; La Pietra, V.; Novellino, E.; Orlandini, E.; Nencetti, S.; Tuccinardi, T.; Martinelli, A.; Lim, N.H.; Visse, R.; Nagase, H.; Rossello, A.
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis
J. Med. Chem.
52
4757-4773
2009
Homo sapiens (P45452)
Fortier, L.A.; Motta, T.; Greenwald, R.A.; Divers, T.J.; Mayr, K.G.
Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1alpha and MMP-13-induced catabolic gene responses
J. Orthop. Res.
28
522-528
2010
Homo sapiens
Julovi, S.M.; Ito, H.; Nishitani, K.; Jackson, C.J.; Nakamura, T.
Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38
J. Orthop. Res.
29
258-264
2010
Homo sapiens
Tabuchi, S.; Sakuta, T.; Oyama, T.; Tokuda, M.; Tatsuyama, S.; Kajihara, T.; Nagaoka, S.; Beppu, M.; Sugihara, K.; Ikebe, T.; Shirasuna, K.; Torii, M.
Runt-related gene 2 is involved in the inhibition of matrix metalloproteinase-13 expression by roxithromycin in human gingival epithelial cell cultures
J. Periodontal Res.
44
283-288
2009
Homo sapiens
Kimura, H.; Yukitake, H.; Suzuki, H.; Tajima, Y.; Gomaibashi, K.; Morimoto, S.; Funabashi, Y.; Yamada, K.; Takizawa, M.
The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death
J. Pharmacol. Sci.
110
201-211
2009
Homo sapiens, Rattus norvegicus
Li, J.J.; Johnson, A.R.
Selective MMP13 inhibitors
Med. Res. Rev.
31
863-894
2011
Homo sapiens, Mus musculus, Rattus norvegicus
Im, H.; Sharrocks, A.; Lin, X.; Yan, D.; Kim, J.; Van Wijnen, A.; Hipskind, R.
Basic fibroblast growth factor induces matrix metalloproteinase-13 via eRK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes
Open Access Rheumatol.
1
151-161
2009
Homo sapiens
Kardesler, L.; Biyikoglu, B.; Cetinkalp, S.; Pitkala, M.; Sorsa, T.; Buduneli, N.
Crevicular fluid matrix metalloproteinase-8, -13, and TIMP-1 levels in type 2 diabetics
Oral Dis.
16
476-481
2010
Homo sapiens
Leonardi, R.; Matthews, J.B.; Caltabiano, R.; Greco, M.; Lombardo, C.; Loreto, C.; Santarelli, A.; Muzio, L.L.
MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts
Oral Dis.
16
795-800
2010
Homo sapiens
Ahmad, R.; El Mabrouk, M.; Sylvester, J.; Zafarullah, M.
Human osteoarthritic chondrocytes are impaired in matrix metalloproteinase-13 inhibition by IFN-gamma due to reduced IFN-gamma receptor levels
Osteoarthritis Cartilage
17
1049-1055
2009
Homo sapiens
Long, D.L.; Loeser, R.F.
p38gamma mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation
Osteoarthritis Cartilage
18
1203-1210
2010
Homo sapiens
Kothapalli, R.; Khan, A.M.; Basappa, A.M.; Gopalsamy, A.; Chong, Y.S.; Annamalai, L.
Cheminformatics-based drug design approach for identification of inhibitors targeting the characteristic residues of MMP-13 hemopexin domain
PLoS ONE
5
e12494
2010
Homo sapiens
Kim, K.S.; Choi, H.M.; Lee, Y.A.; Choi, I.A.; Lee, S.H.; Hong, S.J.; Yang, H.I.; Yoo, M.C.
Expression levels and association of gelatinases MMP-2 and MMP-9 and collagenases MMP-1 and MMP-13 with VEGF in synovial fluid of patients with arthritis
Rheumatol. Int.
31
543-547
2010
Homo sapiens
Cho, B.S.; Roelofs, K.J.; Ford, J.W.; Henke, P.K.; Upchurch, G.R.
Decreased collagen and increased matrix metalloproteinase-13 in experimental abdominal aortic aneurysms in males compared with females
Surgery
147
258-267
2010
Rattus norvegicus
Li, C.H.; Cheng, Y.W.; Liao, P.L.; Yang, Y.T.; Kang, J.J.
Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion
Toxicol. Sci.
116
140-150
2010
Homo sapiens
Giano, M.C.; Pochan, D.J.; Schneider, J.P.
Controlled biodegradation of self-assembling beta-hairpin peptide hydrogels by proteolysis with matrix metalloproteinase-13
Biomaterials
32
6471-6477
2011
Homo sapiens
Fobian, Y.M.; Freskos, J.N.; Barta, T.E.; Bedell, L.J.; Heintz, R.; Kassab, D.J.; Kiefer, J.R.; Mischke, B.V.; Molyneaux, J.M.; Mullins, P.; Munie, G.E.; Becker, D.P.
MMP-13 selective alpha-sulfone hydroxamates: Identification of selective P1 amides
Bioorg. Med. Chem. Lett.
21
2823-2825
2011
Homo sapiens
De Savi, C.; Morley, A.D.; Ting, A.; Nash, I.; Karabelas, K.; Wood, C.M.; James, M.; Norris, S.J.; Karoutchi, G.; Rankine, N.; Hamlin, G.; Macfaul, P.A.; Ryan, D.; Baker, S.V.; Hargreaves, D.; Gerhardt, S.
Selective non zinc binding inhibitors of MMP13
Bioorg. Med. Chem. Lett.
21
4215-4219
2011
Homo sapiens
Tommasi, R.A.; Weiler, S.; McQuire, L.W.; Rogel, O.; Chambers, M.; Clark, K.; Doughty, J.; Fang, J.; Ganu, V.; Grob, J.; Goldberg, R.; Goldstein, R.; Lavoie, S.; Kulathila, R.; Macchia, W.; Melton, R.; Springer, C.; Walker, M.; Zhang, J.; Zhu, L.; Shultz, M.
Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13
Bioorg. Med. Chem. Lett.
21
6440-6445
2011
Homo sapiens
Vicini, P.; Crasc, L.; Incerti, M.; Ronsisvalle, S.; Cardile, V.; Panico, A.
Benzisothiazolyliminothiazolidin-4-ones with chondroprotective properties: Searching for potent and selective inhibitors of MMP-13
ChemMedChem
6
1199-1202
2011
Homo sapiens (P45452)
Zhang, L.; Yang, M.; Yang, D.; Cavey, G.; Davidson, P.; Gibson, G.
Molecular interactions of MMP-13 C-terminal domain with chondrocyte proteins
Connect. Tissue Res.
51
230-239
2010
Homo sapiens
Taylor, S.J.; Abeywardane, A.; Liang, S.; Muegge, I.; Padyana, A.K.; Xiong, Z.; Hill-Drzewi, M.; Farmer, B.; Li, X.; Collins, B.; Li, J.X.; Heim-Riether, A.; Proudfoot, J.; Zhang, Q.; Goldberg, D.; Zuvela-Jelaska, L.; Zaher, H.; Li, J.; Farrow, N.A.
Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13
J. Med. Chem.
54
8174-8187
2011
Homo sapiens
Meierjohann, S.; Hufnagel, A.; Wende, E.; Kleinschmidt, M.A.; Wolf, K.; Friedl, P.; Gaubatz, S.; Schartl, M.
MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation
Mol. Cancer
9
201
2010
Homo sapiens, Mus musculus
Lim, N.; Meinjohanns, E.; Bou-Gharios, G.; Gompels, L.; Nuti, E.; Rossello, A.; Devel, L.; Dive, V.; Meldal, M.; Nagase, H.
In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis
Arthritis Rheumatol.
66
589-598
2014
Mus musculus (P33435), Mus musculus
Naito, S.; Takahashi, T.; Onoda, J.; Yamauchi, A.; Kawai, T.; Kishino, J.; Yamane, S.; Fujii, I.; Fukui, N.; Numata, Y.
Development of a neutralizing antibody specific for the active form of matrix metalloproteinase-13
Biochemistry
51
8877-8884
2012
Homo sapiens (P45452), Homo sapiens
Nara, H.; Sato, K.; Naito, T.; Mototani, H.; Oki, H.; Yamamoto, Y.; Kuno, H.; Santou, T.; Kanzaki, N.; Terauchi, J.; Uchikawa, O.; Kori, M.
Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: Highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1'' binding site
Bioorg. Med. Chem.
22
5487-5505
2014
Homo sapiens (P45452)
Lu, H.; Wang, S.; Li, Q.; Wang, Y.
Design, synthesis and evaluation of 6-oxo-1, 6-dihydropyrimidine-2,5-dicarboxamide derivatives as MMP 13 inhibitors
Chem. Res. Chin. Univ.
29
67-70
2013
Homo sapiens (P45452)
-
Stura, E.A.; Visse, R.; Cuniasse, P.; Dive, V.; Nagase, H.
Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain
FASEB J.
27
4395-4405
2013
Homo sapiens (P45452), Homo sapiens
Howes, J.M.; Bihan, D.; Slatter, D.A.; Hamaia, S.W.; Packman, L.C.; Knauper, V.; Visse, R.; Farndale, R.W.
The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage
J. Biol. Chem.
289
24091-24101
2014
Homo sapiens (P45452)
Nara, H.; Sato, K.; Naito, T.; Mototani, H.; Oki, H.; Yamamoto, Y.; Kuno, H.; Santou, T.; Kanzaki, N.; Terauchi, J.; Uchikawa, O.; Kori, M.
Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach
J. Med. Chem.
57
8886-8902
2014
Homo sapiens (P45452)
Filomia, F.; Saxena, P.; Durante, C.; De Rienzo, F.; Cocchi, M.; Menziani, M.
Computational insights into ADAMTS4, ADAMTS5 and MMP13 inhibitor selectivity
Mol. Inform.
31
421-430
2012
Homo sapiens (P45452)
Zhang, C.; Tang, W.; Li, Y.
Matrix metalloproteinase 13 (MMP13) is a direct target of osteoblast-specific transcription factor osterix (Osx) in osteoblasts
PLoS ONE
7
e50525
2012
Mus musculus (P33435)
Nara, H.; Sato, K.; Kaieda, A.; Oki, H.; Kuno, H.; Santou, T.; Kanzaki, N.; Terauchi, J.; Uchikawa, O.; Kori, M.
Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors
Bioorg. Med. Chem.
24
6149-6165
2016
Homo sapiens (P45452)
Satish Kumar, K.; Velayutham, R.; Roy, K.K.
A systematic computational analysis of human matrix metalloproteinase 13 (MMP-13) crystal structures and structure-based identification of prospective drug candidates as MMP-13 inhibitors repurposable for osteoarthritis
J. Biomol. Struct. Dyn.
12
1-13
2019
Homo sapiens (P45452), Homo sapiens
Waldron, A.L.; Schroder, P.A.; Bourgon, K.L.; Bolduc, J.K.; Miller, J.L.; Pellegrini, A.D.; Dubois, A.L.; Blaszkiewicz, M.; Townsend, K.L.; Rieger, S.
Oxidative stress-dependent MMP-13 activity underlies glucose neurotoxicity
J. Diabetes Complicat.
32
249-257
2018
Danio rerio, Mus musculus (P33435)
Zhang, R.; Zhang, L.; Li, C.; Chen, B.; Li, Q.; Fang, X.; Shen, Y.
Refolding of recombinant histidine-tagged catalytic domain of MMP-13 from escherichia coli with ion-exchange chromatography for higher bioactivity
J. Liq. Chromatogr. Relat. Technol.
38
561-568
2015
Homo sapiens
-
Prystupa, A.; Szpetnar, M.; Boguszewska-Czubara, A.; Grzybowski, A.; Sak, J.; Zaluska, W.
Activity of MMP1 and MMP13 and amino acid metabolism in patients with alcoholic liver cirrhosis
Med. Sci. Monit.
21
1008-1014
2015
Homo sapiens (P45452), Homo sapiens
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