Literature summary for 3.4.24.B4 extracted from

Toriseva, M.J.; Ala-Aho, R.; Karvinen, J.; Baker, A.H.; Marjomaeki, V.S.; Heino, J.; Kaehaeri, V.M.
Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts (2006), J. Invest. Dermatol., 127, 49-59.

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Application

Application	Comment	Organism
medicine	high level of enzyme expression by fibroblasts achieved by adenoviral gene delivery results in potent enhancement of remodeling and contraction of 3D collagen	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	role for enzyme in regulating dermal fibroblast survival, proliferation, and interaction in 3D collagen	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	expression by fibroblasts inadult gingival and in fetal skin wounds characterized by rapid collagen remodeling and scarless healing	Homo sapiens	-
skin	expression by fibroblasts in adult gingival and in fetal skin wounds characterized by rapid collagen remodeling and scarless healing	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	role for enzyme in regulating dermal fibroblast survival, proliferation, and interaction in 3D collagen	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)