Literature summary for 3.4.24.B4 extracted from

Lu, H.; Wang, S.; Li, Q.; Wang, Y.
Design, synthesis and evaluation of 6-oxo-1, 6-dihydropyrimidine-2,5-dicarboxamide derivatives as MMP 13 inhibitors (2013), Chem. Res. Chin. Univ., 29, 67-70.

No PubMed abstract available

Search for more literature for 3.4.24.B4

Inhibitors

Inhibitors	Comment	Organism	Structure
N2,N5-bis(3-methylbenzyl)-6-oxo-1,6-dihydropyrimidine-2,5-dicarboxamide	compound shows about 75fold selectivity over metalloproteases MMP3, MMP12	Homo sapiens
N2,N5-bis(4-fluoro-3-methylbenzyl)-6-oxo-1,6-dihydropyrimidine-2,5-dicarboxamide	compound shows about 65fold and 47fold selectivity over metalloproteases MMP3, MMP12, respectively	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P45452	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000068	-	pH 7.5, 22°C	Homo sapiens	N2,N5-bis(4-fluoro-3-methylbenzyl)-6-oxo-1,6-dihydropyrimidine-2,5-dicarboxamide
0.000096	-	pH 7.5, 22°C	Homo sapiens	N2,N5-bis(3-methylbenzyl)-6-oxo-1,6-dihydropyrimidine-2,5-dicarboxamide

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)