Literature summary for 3.4.24.B4 extracted from

Akhtar, N.; Rasheed, Z.; Ramamurthy, S.; Anbazhagan, A.N.; Voss, F.R.; Haqqi, T.M.
MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes (2010), Arthritis Rheum., 62, 1361-1371.

Search for more literature for 3.4.24.B4

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	secretion of MMP-13 protein to the culture supernatant of chondrocytes	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cartilage	-	Homo sapiens	-
chondrocyte	interleukin-1beta-induced, osteoarthritic	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-13	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	in the chondrocytes pretreated with the JNK inhibitor SP600125, stimulation with interleukin-1beta shows an 88% increase in miR-27b expression and an 14fold increase in MMP-13 mRNA expression compared with controls. Pretreatment of osteoarthritic chondrocytes with the p38 MAPK inhibitor SB202190 suppresses interleukin-1beta-induced MMP-13 mRNA expression by 90%	up

General Information

General Information	Comment	Organism
additional information	interleukin-1beta-induced activation of signal transduction pathways associated with the expression of MMP-13 downregulates the expression of miR-27b micro-RNA. Thus, miR-27b may play a role in regulating the expression of MMP-13 in human chondrocytes, with negative regulation of miR-27b expression by activation of NF-kappaB	Homo sapiens
physiological function	MMPs are important regulators of tissue remodeling and repair	Homo sapiens

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Release 2023.1 (January 2023)