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Literature summary for 3.4.24.B4 extracted from

  • Achari, Y.; Lu, T.; Katzenellenbogen, B.S.; Hart, D.A.
    Distinct roles for AF-1 and -2 of ER-alpha in regulation of MMP-13 promoter activity (2009), Biochim. Biophys. Acta, 1792, 211-220.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HIG-82 cell a synoviocyte cell line Oryctolagus cuniculus
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Synonyms

Synonyms Comment Organism
MMP-13
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Oryctolagus cuniculus

Expression

Organism Comment Expression
Oryctolagus cuniculus 17beta-estadiol reduces the MMP-13 promoter activity down
Oryctolagus cuniculus ER-alpha upregulates MMP-13 expression and acts via an AP-1 regulatory site on the MMP-13 promoter, ER-alpha influences the MMP-13 activity mediated by two separate transcriptional activation domains, AF-1 and AF-2, overview. Both AF-1 and AF-2 domains of ER-alpha are required for regulation of MMP-13 promoter activity up