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Literature summary for 3.4.24.B4 extracted from

  • Inada, M.; Wang, Y.; Byrne, M.H.; Rahman, M.U.; Miyaura, C.; Lopez-Otin, C.; Krane, S.M.
    Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification (2004), Proc. Natl. Acad. Sci. USA, 101, 17192-17197.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine cartilaginous growth plate abnormalities result from enzyme deficiency in mice phenocopy defects observed in human hereditary chondrodysplasis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme-null mice show profound defects in growth plate cartilage with markedly increased hyperthrophic domains and delay in indochondrial ossification and formation and vascularization of primary ossification centers. Cartilaginous growth plate abnormalities persist in adult animals and phenocopy defects observed in human hereditary chondrodysplasis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining