Literature summary for 3.4.24.B4 extracted from

Zhang, X.; Gonnella, N.C.; Koehn, J.; Pathak, N.; Ganu, V.; Melton, R.; Parker, D.; Hu, S.I.; Nam, K.Y.
Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1 (2000), J. Mol. Biol., 301, 513-524.

Search for more literature for 3.4.24.B4

Cloned(Commentary)

Cloned (Comment)	Organism
expression of a truncated enzyme in Escherichia coli BL21(DE3)	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
hydroxamic acid inhibitor CGS 27023	complex formation with the catalytic fragment of the enzyme, inhibitor binding mechanism	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protein + H2O	Homo sapiens	-	peptides	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P45452	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
protein + H2O	-	Homo sapiens	peptides	-	?

Subunits

Subunits	Comment	Organism
More	recombinant catalytic enzyme fragment complexed with a non-peptidic sulfonamide, hydroxamic acid inhibitor CGS 27023, NMR structure determination	Homo sapiens

Synonyms

Synonyms	Comment	Organism
M10.013	Merops-ID	Homo sapiens
matrix metalloproteinase-13	-	Homo sapiens
MMP-13	-	Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
additional information	-	the recombinant catalytic enzyme fragment complexed with a non-peptidic sulfonamide inhibitor CGS 27023 is stable up to 45°C, denaturation and precipitation occurs at temperatures exceeding 50°C	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000019	-	hydroxamic acid inhibitor CGS 27023	pH 6.8	Homo sapiens

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Release 2023.1 (January 2023)