Cloned (Comment) | Organism |
---|---|
MMP13 real-time RT-PCR expression analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P45452 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
giant cell tumor cell | MMP-13 is the principal proteinase expressed by the mesenchymal stromal cells of giant cell tumor | Homo sapiens | - |
additional information | immunohistochemic MMP13 expression analysis | Homo sapiens | - |
stromal cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | siRNA knockdown of transcription factor Runx2 decreases MMP-13 expression in giant cell tumor stromal cells | down |
Homo sapiens | the Runx2 transcription factor is known to have a binding site in the MMP-13 promoter region and activates MMP-13 expression constitutively in giant cell tumor cells. Inhibition of the ERK and JNK signaling pathways inhibits the upregulation of MMP-13 in these cells | up |