Literature summary for 3.4.24.B4 extracted from

Yang, L.; Guo, A.; Gu, J.C.
c-Jun N-terminal kinase and nuclear factor kappaB mediate nitric oxide-induced expression of matrix metalloproteinase-13 (2011), Int. Orthop., 35, 1261-1266.

Search for more literature for 3.4.24.B4

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondrocyte	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-13	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	(Z)-1-[N-methyl-N-[6-(N-methylammoniohexyl)amino]]diazen-1-ium-1,2-diolate, i.e. MAHMA-NONOate, induces the expression of MMP-13 via release of NO, which induces MMP-13 expression by JNK and NF-kappaB activation in chondrocytes, mechanism, overview. NO-induced MMP-13 expression is not suppressed by extracellular signal-regulated kinase inhibitor PD98059, or inhibitors of p38 kinase, i.e. SB203580, but is inhibited by a c-jun terminal kinase inhibitor SP600125 and inhibitors of NF-kappaB, i.e. SN-50	up

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Release 2023.1 (January 2023)