Any feedback?
Literature summary for 3.4.24.B4 extracted from
- MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma (2010), Carcinogenesis, 31, 1175-1184.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| realtime RT-PCR MMP13 expression analysis, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular matrix | - |
Mus musculus | 31012 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Collagen IV + H2O | Mus musculus | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 mice, wild-type and MMP13-/- mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
| additional information | realtime RT-PCR MMP13 expression analysis, overview | Mus musculus | - |
| squamous cell carcinoma cell | induced tumors, stromal MMP13 is associated with vascular endothelial growth factor receptor-2 on endothelial cells in invasive areas. Tumour invasion was downregulated in Mmp13-/- animals. Kinetics of angiogenesis and tumour growth in surface transplants, overview | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Collagen IV + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| collagenase | - |
Mus musculus |
| MMP13 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | MMP13 has an essential role in highly malignant and invasive growth in skin squamous cell carcinoma. Lack of host MMP13 strongly impairs implanted tumour growth of malignant skin squamous cell carcinoma cells, leading to small, mostly avascular cysts. MMP13 is essential for maintenance of angiogenesis and for invasion | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
