Literature summary for 3.4.24.B4 extracted from

Barmina, O.Y.; Walling, H.W.; Fiacco, G.J.; Freije, J.M.; Lopez-Otin, C.; Jeffrey, J.J.; Partridge, N.C.
Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalization (1999), J. Biol. Chem., 274, 30087-30093.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	secretion	Rattus norvegicus	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	Ca2+-dependent binding to the specific receptor of osteoblastic and fibroblastic cell lines via residue I125	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	osteoblastic osteosarcoma cell line UMR 106-01, Ca2+-dependent binding in a two-step mechanism via the required specific 170 kDa enzyme receptor and the required 600 kDa LDL-receptor, internalization and degradation of the enzyme, modeling, the enzyme also binds to mouse fibroblastic cells	?	-	?
protein + H2O	Rattus norvegicus	-	peptides	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
purification of the secreted enzyme from the cell culture medium	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
cell culture	uterine smooth muscle cells	Rattus norvegicus	-
additional information	osteoblastic osteosarcoma cell line UMR 106-01, Ca2+-dependent binding in a two-step mechanism via the required specific enzyme receptor and LDL-receptor-related protein, internalization and degradation of the enzyme, also binding to fibroblastic cells	Rattus norvegicus	-
smooth muscle	-	Rattus norvegicus	-
uterus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	osteoblastic osteosarcoma cell line UMR 106-01, Ca2+-dependent binding in a two-step mechanism via the required specific 170 kDa enzyme receptor and the required 600 kDa LDL-receptor, internalization and degradation of the enzyme, modeling, the enzyme also binds to mouse fibroblastic cells	Rattus norvegicus	?	-	?
protein + H2O	-	Rattus norvegicus	peptides	-	?

Synonyms

Synonyms	Comment	Organism
M10.013	Merops-ID	Rattus norvegicus
matrix metalloproteinase-13	-	Rattus norvegicus
MMP-13	-	Rattus norvegicus

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Release 2023.1 (January 2023)