Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-2-(4-(2-(biphenyl-4-yl)vinyl)-N-isopropoxyphenylsulfonamido)-N-hydroxyacetamide | - |
Homo sapiens | |
(R)-2-(4'-(4-chlorobenzyloxy)-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxy-3-methylbutanamide | - |
Homo sapiens | |
2-(4'-(4-chlorobenzyloxy)-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxyacetamide | - |
Homo sapiens | |
2-(4'-butoxy-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxyacetamide | - |
Homo sapiens | |
2-(5-((4-butylphenyl)ethynyl)-N-isopropoxythiophene-2-sulfonamido)-N-hydroxyacetamide | - |
Homo sapiens | |
2-(5-(4-ethylphenyl)-N-isopropoxythiophene-2-sulfonamido)-N-hydroxyacetamide | - |
Homo sapiens | |
2-(5-(4-fluorophenyl)-N-isopropoxythiophene-2-sulfonamido)-N-hydroxyacetamide | - |
Homo sapiens | |
additional information | design, synthesis and biological evaluation of selective matrix metalloproteinase-13 N-O-isopropyl sulfonamido-based hydroxamate inhibitors as potential therapeutic agents for osteoarthritis, docking study and molecular modelling, overview | Homo sapiens | |
N-hydroxy-2-(N-isopropoxy-4'-(methylthio)biphenyl-4-ylsulfonamido)acetamide | - |
Homo sapiens | |
N-hydroxy-2-(N-isopropoxy-4'-methoxybiphenyl-4-ylsulfonamido)acetamide | - |
Homo sapiens | |
N-hydroxy-2-(N-isopropoxy-4-phenoxyphenylsulfonamido)-acetamide | - |
Homo sapiens | |
N-hydroxy-2-(N-isopropoxy-5-(4-methoxyphenyl)thiophene-2-sulfonamido)acetamide | - |
Homo sapiens | |
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(2-methylpropyl)glycinamide | - |
Homo sapiens | |
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)-L-valinamide | - |
Homo sapiens | |
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide | - |
Homo sapiens | |
N2-(biphenyl-4-ylsulfonyl)-N-hydroxyglycinamide | - |
Homo sapiens | |
N2-({4'-[(4-chlorobenzyl)oxy]biphenyl-4-yl}sulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular matrix | - |
Homo sapiens | 31012 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Collagen + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P45452 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, overview | Homo sapiens | |
0.0000015 | - |
N2-(biphenyl-4-ylsulfonyl)-N-hydroxyglycinamide | pH not specified in the publication, 25°C | Homo sapiens | |
0.0000015 | - |
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)-L-valinamide | pH not specified in the publication, 25°C | Homo sapiens | |
0.0000058 | - |
N-hydroxy-2-(N-isopropoxy-4'-methoxybiphenyl-4-ylsulfonamido)acetamide | pH not specified in the publication, 25°C | Homo sapiens | |
0.0000082 | - |
N2-({4'-[(4-chlorobenzyl)oxy]biphenyl-4-yl}sulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide | pH not specified in the publication, 25°C | Homo sapiens | |
0.00002 | - |
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide | pH not specified in the publication, 25°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000028 | - |
pH not specified in the publication, 25°C | Homo sapiens | N2-(biphenyl-4-ylsulfonyl)-N-hydroxyglycinamide | |
0.000003 | - |
pH not specified in the publication, 25°C | Homo sapiens | (R)-2-(4'-(4-chlorobenzyloxy)-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxy-3-methylbutanamide | |
0.0000072 | - |
pH not specified in the publication, 25°C | Homo sapiens | N-hydroxy-2-(N-isopropoxy-4'-(methylthio)biphenyl-4-ylsulfonamido)acetamide | |
0.00001 | - |
pH not specified in the publication, 25°C | Homo sapiens | N-hydroxy-2-(N-isopropoxy-4'-methoxybiphenyl-4-ylsulfonamido)acetamide | |
0.000015 | - |
pH not specified in the publication, 25°C | Homo sapiens | 2-(4'-butoxy-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxyacetamide | |
0.000019 | - |
pH not specified in the publication, 25°C | Homo sapiens | 2-(4'-(4-chlorobenzyloxy)-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxyacetamide | |
0.000025 | - |
pH not specified in the publication, 25°C | Homo sapiens | N-hydroxy-2-(N-isopropoxy-5-(4-methoxyphenyl)thiophene-2-sulfonamido)acetamide | |
0.000039 | - |
pH not specified in the publication, 25°C | Homo sapiens | N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(2-methylpropyl)glycinamide | |
0.000041 | - |
pH not specified in the publication, 25°C | Homo sapiens | (E)-2-(4-(2-(biphenyl-4-yl)vinyl)-N-isopropoxyphenylsulfonamido)-N-hydroxyacetamide | |
0.000045 | - |
pH not specified in the publication, 25°C | Homo sapiens | N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide | |
0.000063 | - |
pH not specified in the publication, 25°C | Homo sapiens | N-hydroxy-2-(N-isopropoxy-4-phenoxyphenylsulfonamido)-acetamide | |
0.000091 | - |
pH not specified in the publication, 25°C | Homo sapiens | 2-(5-(4-ethylphenyl)-N-isopropoxythiophene-2-sulfonamido)-N-hydroxyacetamide | |
0.00026 | - |
pH not specified in the publication, 25°C | Homo sapiens | 2-(5-((4-butylphenyl)ethynyl)-N-isopropoxythiophene-2-sulfonamido)-N-hydroxyacetamide | |
0.0006 | - |
pH not specified in the publication, 25°C | Homo sapiens | 2-(5-(4-fluorophenyl)-N-isopropoxythiophene-2-sulfonamido)-N-hydroxyacetamide |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-13 is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis | Homo sapiens |