Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.B4 extracted from

  • Mak, I.W.; Seidlitz, E.P.; Cowan, R.W.; Turcotte, R.E.; Popovic, S.; Wu, W.C.; Singh, G.; Ghert, M.
    Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone (2010), Hum. Pathol., 41, 1320-1329.
    View publication on PubMed
Search for more literature for 3.4.24.B4

Inhibitors

Inhibitors Comment Organism Structure
CP-471474
-
 Homo sapiens
CP-471474
-
 Mus musculus
PD-331179
-
 Homo sapiens
PD-331179
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular MMP-13 is secreted Mus musculus
-
-
extracellular MMP-13 is secreted Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required for catalysis Mus musculus
Zn2+ required for catalysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Type I collagen + H2O Mus musculus
-
 ?
-
 ?
Type I collagen + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Mus musculus
-
bone
-
 Homo sapiens
-
giant cell tumor cell
-
 Mus musculus
-
giant cell tumor cell
-
 Homo sapiens
-
HFOB 1.19 cell fetal osteoblasts Homo sapiens
-
RAW-264.7 cell
-
 Mus musculus
-
stromal cell mesenchymal Mus musculus
-
stromal cell mesenchymal Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O
-
 Mus musculus ?
-
 ?
Type I collagen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-13
-
 Mus musculus
MMP-13
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function inhibition of MMP-13 reduces resorptive activity of the cells indicating that MMP-13 likely plays an important role in bone giant cell tumor. Mesenchymal stromal cells and the multinucleated giant cells cell-cell cooperation involves giant cell-derived cytokine up-regulation of MMP-13 in the stromal cells, which in turn assists the giant cells in bone resorption Mus musculus
physiological function inhibition of MMP-13 reduces resorptive activity of the cells indicating that MMP-13 likely plays an important role in bone giant cell tumor. Mesenchymal stromal cells and the multinucleated giant cells cell-cell cooperation involves giant cell-derived cytokine up-regulation of MMP-13 in the stromal cells, which in turn assists the giant cells in bone resorption Homo sapiens