Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid | binding structure, modelling, overview | Homo sapiens | |
2,3-dihydro-1,4-benzodioxine-2-carboxylic acid | binding structure, modelling, overview | Homo sapiens | |
2,3-dihydro-1,4-benzodioxine-5-carboxylic acid | binding structure, modelling, overview | Homo sapiens | |
2-(2-[(2-chlorobenzoyl)amino]-1,3-thiazol-4-yl)acetic acid | binding structure, modelling, overview | Homo sapiens | |
2-fluoroisophthalic acid | binding structure, modelling, overview | Homo sapiens | |
3-(carboxymethyl)-2-methylenepentanedioic acid | binding structure, modelling, overview | Homo sapiens | |
6-hydroxy-2-(methylsulfanyl)-4-pyrimidinecarboxylic acid | binding structure, modelling, overview | Homo sapiens | |
additional information | selective inhibition of MMP-13 may be achieved by targeting the hemopexin domain of the protease, which is critical for substrate specificity, systematic cheminformatics-based drug design with virtual screening, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | MMP-13 is a zinc-dependent protease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
type II collagen + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | MMP-13 is expressed in osteoarthritis and rheumatoid arthritis patients, but not in normal adult tissues | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
type II collagen + H2O | - |
Homo sapiens | ? | - |
? | |
type II collagen + H2O | the hemopexin domain of the protease is critical for substrate specificity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Homo sapiens |