Cloned (Comment) | Organism |
---|---|
reverse transcription-PCR expression analysis of MMP13 in wild-type and mutant mice, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of MMP13 and MMP13/MMP9 knockout mice, that all show delayed wound closure compared to wild-type mice. The rate of re-epithelialization is significantly delayed in MMP-9 KO and MMP-13 KO mice and remarkably delayed in MMP-9/13 double KO mice, phenotype, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BB94 | a broadspectrum MMP inhibitor, significantly inhibits keratinocyte migration | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular matrix | - |
Mus musculus | 31012 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
129/Sv and C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | expression analysis of MMP13 in healthy and wounded skin, overview | Mus musculus | - |
skin | MMP-13 expression is negligible in the normal unwounded skin at day 0, but it increases on days 1 to 7 upon wounding, diminishes on day 14 and disappears on day 28 | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | keratinocytes transfected with siRNA for MMP-13 exhibit downregulation of mRNA and protein expression of the MMP | down |
Mus musculus | MMP13 expression is transiently induced by wounding, MMP-13 expression is negligible in the normal unwounded skin at day 0, but it increases on days 1 to 7 upon wounding, diminishes on day 14 and disappears on day 28 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP13 affects the keratinocyte migration in the skin, overview. Connective tissue growth factor, CTGF, blocks angiogenic activity of vascular epithelial growth factor, VEGF, by complex formation, and MMP13 re-activates VEGF activity through selective cleavage of CTGF in the complex | Mus musculus |