3.4.22.B70: SENP1 peptidase

This is an abbreviated version, for detailed information about SENP1 peptidase, go to the full flat file.

Reaction

The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO-1, SUMO-2 and SUMO-3 from targeted proteins. Deconjugates SUMO-1 from homeodomain-interacting protein kinase 2. Deconjugates SUMO-1 from histone deacetylase 1, which decreases its transcriptional repression activity. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. =

Synonyms

C13orf22l, SENP, SENP1, sentrin-specific protease 1, sentrin/SUMO-specific protease 1, small ubiquitin-like modifier protein-specific protease 1, small ubiquitin-related modifier-specific isopeptidase, SUMO isopeptidase, SUMO protease, SUMO protein-specific protease 1, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 1, ubiquitin-specific protease-like 1, USPL1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B70 SENP1 peptidase

Reference

Reference on EC 3.4.22.B70 - SENP1 peptidase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, Z.; Chau, S.F.; Lam, K.H.; Chan, H.Y.; Ng, T.B.; Au, S.W.
Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease
Biochem. J.
398
345-352
2006
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Cheng, J.; Kang, X.; Zhang, S.; Yeh, E.T.
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
Cell
131
584-595
2007
Mus musculus (P59110)
Manually annotated by BRENDA team
Bawa-Khalfe, T.; Cheng, J.; Wang, Z.; Yeh, E.T.
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells
J. Biol. Chem.
282
37341-37349
2007
Homo sapiens
Manually annotated by BRENDA team
Shen, L.; Tatham, M.H.; Dong, C.; Zagorska, A.; Naismith, J.H.; Hay, R.T.
SUMO protease SENP1 induces isomerization of the scissile peptide bond
Nat. Struct. Mol. Biol.
13
1069-1077
2006
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Rimsa, V.; Eadsforth, T.; Hunter, W.N.
The role of Co2+ in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols
Acta Crystallogr. Sect. F
67
442-445
2011
Homo sapiens, Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Yates, K.E.; Korbel, G.A.; Shtutman, M.; Roninson, I.B.; DiMaio, D.
Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts
Aging Cell
7
609-621
2008
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Ohbayashi, N.; Kawakami, S.; Muromoto, R.; Togi, S.; Ikeda, O.; Kamitani, S.; Sekine, Y.; Honjoh, T.; Matsuda, T.
The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
Biochem. Biophys. Res. Commun.
371
823-828
2008
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Xu, Z.; Au, S.W.
Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1
Biochem. J.
386
325-330
2005
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Shen, L.N.; Dong, C.; Liu, H.; Naismith, J.H.; Hay, R.T.
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing
Biochem. J.
397
279-288
2006
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Witty, J.; Aguilar-Martinez, E.; Sharrocks, A.D.
SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
Biochem. J.
428
247-254
2010
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Brems-Eskildsen, A.S.; Zieger, K.; Toldbod, H.; Holcomb, C.; Higuchi, R.; Mansilla, F.; Munksgaard, P.P.; Borre, M.; Orntoft, T.F.; Dyrskjot, L.
Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts
BMC Cancer
10
646
2010
Homo sapiens
Manually annotated by BRENDA team
Xu, Y.; Li, J.; Zuo, Y.; Deng, J.
Wang, L.S.; Chen, G.Q.: SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors
Cancer Lett.
309
78-84
2011
Homo sapiens
Manually annotated by BRENDA team
Li, X.; Luo, Y.; Yu, L.; Lin, Y.; Luo, D.; Zhang, H.; He, Y.; Kim, Y.O.; Kim, Y.; Tang, S.; Min, W.
SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis
Cell Death Differ.
15
739-750
2008
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Dai, X.Q.; Plummer, G.; Casimir, M.; Kang, Y.; Hajmrle, C.; Gaisano, H.Y.; Manning Fox, J.E.; MacDonald, P.E.
SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans
Diabetes
60
838-847
2011
Mus musculus (P59110)
Manually annotated by BRENDA team
Kim, Y.H.; Sung, K.S.; Lee, S.J.; Kim, Y.O.; Choi, C.Y.; Kim, Y.
Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1
FEBS Lett.
579
6272-6278
2005
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Bawa-Khalfe, T.; Yeh, E.T.
SUMO losing balance: SUMO proteases disrupt SUMO homeostasis to facilitate cancer development and progression
Genes Cancer
1
748-752
2010
Homo sapiens
Manually annotated by BRENDA team
Bailey, D.; O'Hare, P.
Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1
J. Biol. Chem.
279
692-703
2004
Homo sapiens
Manually annotated by BRENDA team
Bawa-Khalfe, T.; Cheng, J.; Lin, S.H.; Ittmann, M.M.; Yeh, E.T.
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms
J. Biol. Chem.
285
25859-25866
2010
Mus musculus (P59110)
Manually annotated by BRENDA team
Xu, Y.; Zuo, Y.; Zhang, H.; Kang, X.; Yue, F.; Yi, Z.; Liu, M.; Yeh, E.T.; Chen, G.; Cheng, J.
Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis
J. Biol. Chem.
285
36682-36688
2010
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Yu, L.; Ji, W.; Zhang, H.; Renda, M.J.; He, Y.; Lin, S.; Cheng, E.C.; Chen, H.; Krause, D.S.; Min, W.
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis
J. Exp. Med.
207
1183-1195
2010
Mus musculus (P59110)
Manually annotated by BRENDA team
Cheng, J.; Wang, D.; Wang, Z.; Yeh, E.T.
SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1
Mol. Cell. Biol.
24
6021-6028
2004
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Kaikkonen, S.; Jääskeläinen, T.; Karvonen, U.; Rytinki, M.M.; Makkonen, H.; Gioeli, D.; Paschal, B.M.; Palvimo, J.J.
SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells
Mol. Endocrinol.
23
292-307
2009
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Shin, Y.C.; Liu, B.Y.; Tsai, J.Y.; Wu, J.T.; Chang, L.K.; Chang, S.C.
Biochemical characterization of the small ubiquitin-like modifiers of Chlamydomonas reinhardtii
Planta
232
649-662
2010
Homo sapiens
Manually annotated by BRENDA team
Plant, L.D.; Dementieva, I.S.; Kollewe, A.; Olikara, S.; Marks, J.D.; Goldstein, S.A.
One SUMO is sufficient to silence the dimeric potassium channel K2P1
Proc. Natl. Acad. Sci. USA
107
10743-10748
2010
Homo sapiens, Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Qiao, Z.; Wang, W.; Wang, L.; Wen, D.; Zhao, Y.; Wang, Q.; Meng, Q.; Chen, G.; Wu, Y.; Zhou, H.
Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors
Bioorg. Med. Chem. Lett.
21
6389-6392
2011
Homo sapiens
Manually annotated by BRENDA team
Chen, Y.; Wen, D.; Huang, Z.; Huang, M.; Luo, Y.; Liu, B.; Lu, H.; Wu, Y.; Peng, Y.; Zhang, J.
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation
Bioorg. Med. Chem. Lett.
22
6867-6870
2012
Homo sapiens
Manually annotated by BRENDA team
Yan, X.M.; Xu, Z.Q.; Zhou, Y.; Wang, J.; Pan, J.; Yuan, L.Q.; Fu, M.C.; Xia, H.L.; Cao, X.; Zhang, T.
SENP1 regulates cell migration and invasion in neuroblastoma
Biotechnol. Appl. Biochem.
63
435-440
2016
Homo sapiens
Manually annotated by BRENDA team
Chen, C.H.; Chang, C.C.; Lee, T.H.; Luo, M.; Huang, P.; Liao, P.H.; Wei, S.; Li, F.A.; Chen, R.H.; Zhou, X.Z.; Shih, H.M.; Lu, K.P.
SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function
Cancer Res.
73
3951-3962
2013
Homo sapiens
Manually annotated by BRENDA team
Sharma, P.; Yamada, S.; Lualdi, M.; Dasso, M.; Kuehn, M.R.
Senp1 is essential for desumoylating Sumo1-modified proteins but dispensable for Sumo2 and Sumo3 deconjugation in the mouse embryo
Cell Rep.
3
1640-1650
2013
Mus musculus
Manually annotated by BRENDA team
Schulz, S.; Chachami, G.; Kozaczkiewicz, L.; Winter, U.; Stankovic-Valentin, N.; Haas, P.; Hofmann, K.; Urlaub, H.; Ovaa, H.; Wittbrodt, J.; Meulmeester, E.; Melchior, F.
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions
EMBO Rep.
13
930-938
2012
Danio rerio, Homo sapiens (Q5W0Q7)
Manually annotated by BRENDA team
Cai, R.; Yu, T.; Huang, C.; Xia, X.; Liu, X.; Gu, J.; Xue, S.; Yeh, E.T.; Cheng, J.
SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1alpha
J. Biol. Chem.
287
44464-44470
2012
Homo sapiens
Manually annotated by BRENDA team
Liu, B.; Wang, T.; Mei, W.; Li, D.; Cai, R.; Zuo, Y.; Cheng, J.
Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation
J. Biol. Chem.
289
22358-22364
2014
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Cubenas-Potts, C.; Goeres, J.D.; Matunis, M.J.
SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis
Mol. Biol. Cell
24
3483-3495
2013
Homo sapiens (Q9P0U3)
Manually annotated by BRENDA team
Chow, K.H.; Elgort, S.; Dasso, M.; Powers, M.A.; Ullman, K.S.
The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function
Mol. Biol. Cell
25
160-168
2014
Homo sapiens
Manually annotated by BRENDA team
Chen, C.H.; Namanja, A.T.; Chen, Y.
Conformational flexibility and changes underlying activation of the SUMO-specific protease SENP1 by remote substrate binding
Nat. Commun.
5
4968
2014
Homo sapiens
Manually annotated by BRENDA team
Chow, K.H.; Elgort, S.; Dasso, M.; Ullman, K.S.
Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2
Nucleus
3
349-358
2012
Homo sapiens
Manually annotated by BRENDA team
Wu, R.; Cui, Y.; Yuan, X.; Yuan, H.; Wang, Y.; He, J.; Zhao, J.; Peng, S.
SUMO-specific protease 1 modulates cadmium-augmented transcriptional activity of androgen receptor (AR) by reversing AR SUMOylation
Toxicol. Lett.
229
405-413
2014
Homo sapiens
Manually annotated by BRENDA team
Ma, C.; Wu, B.; Huang, X.; Yuan, Z.; Nong, K.; Dong, B.; Bai, Y.; Zhu, H.; Wang, W.; Ai, K.
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9
Tumour Biol.
35
12729-12735
2014
Homo sapiens
Manually annotated by BRENDA team