3.4.22.B70: SENP1 peptidase

This is an abbreviated version, for detailed information about SENP1 peptidase, go to the full flat file.

Reaction

The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO-1, SUMO-2 and SUMO-3 from targeted proteins. Deconjugates SUMO-1 from homeodomain-interacting protein kinase 2. Deconjugates SUMO-1 from histone deacetylase 1, which decreases its transcriptional repression activity. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. =

Synonyms

C13orf22l, SENP, SENP1, sentrin-specific protease 1, sentrin/SUMO-specific protease 1, small ubiquitin-like modifier protein-specific protease 1, small ubiquitin-related modifier-specific isopeptidase, SUMO isopeptidase, SUMO protease, SUMO protein-specific protease 1, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 1, ubiquitin-specific protease-like 1, USPL1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B70 SENP1 peptidase

Natural Substrates Products

Natural Substrates Products on EC 3.4.22.B70 - SENP1 peptidase

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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(SUMO-1)-androgen receptor conjugate + H2O
SUMO-1 + androgen receptor conjugate
show the reaction diagram
-
SENP1 markedly contributes to the androgen-stimulated proliferation of prostate cancer cells
-
-
?
(SUMO-1)-histone deacetylase 1 conjugate + H2O
SUMO-1 + histone deacetylase 1
show the reaction diagram
-
SENP1 regulates that androgen receptor-dependent transcription through desumoylation of histone deacetylase 1 (HDAC1)
-
-
?
(SUMO-1)-homeodomain-interacting protein kinase 2 conjugate + H2O
SUMO-1 + homeodomain-interacting protein kinase 2 conjugate
show the reaction diagram
-
desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) may be regulated by the cytoplasmic-nuclear shuttling of SENP1. Desumoylation induces dissociation of homeodomain-interacting protein kinase 2 conjugate from nuclear bodies
-
-
?
(SUMO-1)-K2P1 potassium channel + H2O
SUMO-1 + K2P1 potassium channel
show the reaction diagram
-
silent K2P1 channels in excised plasma membrane patches are activated by SENP1
-
-
?
Pin1 + H2O
?
show the reaction diagram
-
Pin1 is SUMOylated on Lys6 in the WW domain and on Lys63 in the PPIase domain, deSUMOlation by SENP1
-
-
?
pro-small ubiquitin-related modifier + H2O
small ubiquitin-related modifier + ?
show the reaction diagram
-
SENP1 processes the precursor SUMO to its mature form by catalyzing the cleavage of a scissile peptide bond
-
-
?
Sharp-1 protein + H2O
?
show the reaction diagram
-
deSUMOylation by the enzyme
-
-
?
small ubiquitin-related modifier-protein + H2O
small ubiquitin-related modifier-protein + protein
show the reaction diagram
-
SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins
-
-
r
SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
show the reaction diagram
-
cleavage of the -Gly-Gly-/-His-Ser-Thr-Val bond. The maturation reaction is the first committed step for subsequent sumoylation
-
-
?
SUMO-2 precursor + H2O
SUMO-2 + Val-Tyr
show the reaction diagram
-
cleavage of the -Gly-Gly-/-Val-Tyr. The maturation reaction is the first committed step for subsequent sumoylation
-
-
?
SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
show the reaction diagram
-
cleavage of the -Gly-Gly-/-Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe bond. The maturation reaction is the first committed step for subsequent sumoylation
-
-
?
SUMO-Elk-1 conjugate + H2O
SUMO + Elk-1
show the reaction diagram
-
SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
-
-
?
SUMO-GATA 1 conjugate + H2O
SUMO + GATA1
show the reaction diagram
-
SENP1 promotes GATA1 activation and subsequent erythropoiesis by deSUMOylating GATA1
-
-
?
SUMO-hypoxia-inducible factor 1 conjugate + H2O
SUMO + hypoxia-inducible factor 1
show the reaction diagram
SUMO-STAT3 protein conjugate + H2O
SUMO + STAT3 protein
show the reaction diagram
-
-
-
-
?
SUMO1ylated protein + H2O
SUMO1 + protein
show the reaction diagram
-
main substrate
-
-
?
SUMO2ylated protein + H2O
SUMO2 + protein
show the reaction diagram
-
-
-
-
?
SUMO3ylated protein + H2O
SUMO3 + protein
show the reaction diagram
-
-
-
-
?
additional information
?
-