3.4.22.B70: SENP1 peptidase
This is an abbreviated version!
For detailed information about SENP1 peptidase, go to the full flat file.
Word Map on EC 3.4.22.B70
-
3.4.22.B70
-
desumoylation
-
deconjugating
-
senp-1
-
medicine
-
sumo-modified
-
senp1-mediated
-
drug development
-
ranbp2
-
sumo-2
-
diagnostics
- 3.4.22.B70
-
desumoylation
-
deconjugating
-
senp-1
- medicine
-
sumo-modified
-
senp1-mediated
- drug development
- ranbp2
- sumo-2
- diagnostics
Reaction
The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO-1, SUMO-2 and SUMO-3 from targeted proteins. Deconjugates SUMO-1 from homeodomain-interacting protein kinase 2. Deconjugates SUMO-1 from histone deacetylase 1, which decreases its transcriptional repression activity. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. =
Synonyms
C13orf22l, SENP, SENP1, sentrin-specific protease 1, sentrin/SUMO-specific protease 1, small ubiquitin-like modifier protein-specific protease 1, small ubiquitin-related modifier-specific isopeptidase, SUMO isopeptidase, SUMO protease, SUMO protein-specific protease 1, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 1, ubiquitin-specific protease-like 1, USPL1
ECTree
3.4.22.B70 SENP1 peptidaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.B70 - SENP1 peptidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(SUMO-1)-androgen receptor conjugate + H2O
SUMO-1 + androgen receptor conjugate
SENP1 markedly contributes to the androgen-stimulated proliferation of prostate cancer cells
-
-
?
(SUMO-1)-histone deacetylase 1 conjugate + H2O
SUMO-1 + histone deacetylase 1
SENP1 regulates that androgen receptor-dependent transcription through desumoylation of histone deacetylase 1 (HDAC1)
-
-
?
(SUMO-1)-homeodomain-interacting protein kinase 2 conjugate + H2O
SUMO-1 + homeodomain-interacting protein kinase 2 conjugate
desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) may be regulated by the cytoplasmic-nuclear shuttling of SENP1. Desumoylation induces dissociation of homeodomain-interacting protein kinase 2 conjugate from nuclear bodies
-
-
?
(SUMO-1)-K2P1 potassium channel + H2O
SUMO-1 + K2P1 potassium channel
silent K2P1 channels in excised plasma membrane patches are activated by SENP1
-
-
?
Pin1 + H2O
?
-
Pin1 is SUMOylated on Lys6 in the WW domain and on Lys63 in the PPIase domain, deSUMOlation by SENP1
-
-
?
pro-small ubiquitin-related modifier + H2O
small ubiquitin-related modifier + ?
-
SENP1 processes the precursor SUMO to its mature form by catalyzing the cleavage of a scissile peptide bond
-
-
?
small ubiquitin-related modifier-protein + H2O
small ubiquitin-related modifier-protein + protein
-
SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins
-
-
r
SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
cleavage of the -Gly-Gly-/-His-Ser-Thr-Val bond. The maturation reaction is the first committed step for subsequent sumoylation
-
-
?
SUMO-2 precursor + H2O
SUMO-2 + Val-Tyr
cleavage of the -Gly-Gly-/-Val-Tyr. The maturation reaction is the first committed step for subsequent sumoylation
-
-
?
SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
cleavage of the -Gly-Gly-/-Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe bond. The maturation reaction is the first committed step for subsequent sumoylation
-
-
?
SUMO-Elk-1 conjugate + H2O
SUMO + Elk-1
SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
-
-
?
SUMO-GATA 1 conjugate + H2O
SUMO + GATA1
SENP1 promotes GATA1 activation and subsequent erythropoiesis by deSUMOylating GATA1
-
-
?
SUMO-hypoxia-inducible factor 1 conjugate + H2O
SUMO + hypoxia-inducible factor 1
-
-
-
?
SUMO-hypoxia-inducible factor 1 conjugate + H2O
SUMO + hypoxia-inducible factor 1
deSUMOylation plays a critical role in prostate pathogenesis through induction of HIF1alpha-dependent angiogenesis and enhanced cell proliferation
-
-
?
additional information
?
-
-
enzyme USPL1 neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase both in vitro and in cells
-
-
?
additional information
?
-
enzyme USPL1 neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase both in vitro and in cells
-
-
?
additional information
?
-
-
nucleoporin Nup153 binds to SENP1 by interacting with the unique N-terminal domain of Nup153 as well as a specific region within the C-terminal FG-rich region. Nup153 is a substrate for SUMOylation, with this modification kept in check by the SUMO protease
-
-
?
additional information
?
-
-
the enzyme SUMO protease removes SUMO conjugate from proteins
-
-
?
