3.4.22.B70: SENP1 peptidase

This is an abbreviated version!
For detailed information about SENP1 peptidase, go to the full flat file.

Reaction

The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO-1, SUMO-2 and SUMO-3 from targeted proteins. Deconjugates SUMO-1 from homeodomain-interacting protein kinase 2. Deconjugates SUMO-1 from histone deacetylase 1, which decreases its transcriptional repression activity. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. =

Synonyms

C13orf22l, SENP, SENP1, sentrin-specific protease 1, sentrin/SUMO-specific protease 1, small ubiquitin-like modifier protein-specific protease 1, small ubiquitin-related modifier-specific isopeptidase, SUMO isopeptidase, SUMO protease, SUMO protein-specific protease 1, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 1, ubiquitin-specific protease-like 1, USPL1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B70 SENP1 peptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
3	AA Sequence
11	Application
14	Cloned(Commentary)
3	Crystallization (Commentary)
106	Disease/ Diagnostics
6	Expression
48	General Information
21	IC50 Value
47	Inhibitors
5	KM Value [mM]
19	Localization
2	Metals/Ions
1	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
46	Organism
2	pH Optimum
1	Posttranslational Modification
27	Protein Variants
6	Purification (Commentary)
1	Reaction
46	Reference
39	Source Tissue
67	Substrates and Products (Substrate)
1	Subunits
54	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
4	Turnover Number [1/s]

Turnover Number

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Turnover Number on EC 3.4.22.B70 - SENP1 peptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Turnover Number Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

8.3

(SUMO-1)-RanGAP1 conjugate

Homo sapiens

Q9P0U3

pH 7.5, 30°C

682081

-

18.2

(SUMO-2)-RanGAP1 conjugate

Homo sapiens

Q9P0U3

pH 7.5, 30°C

682081

-

3.7

SUMO-1 precursor

Homo sapiens

Q9P0U3

pH 7.5, 30°C

682081

-

0.075

SUMO-2 precursor

Homo sapiens

Q9P0U3

pH 7.5, 30°C

682081

-