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Literature summary for 3.4.22.B70 extracted from

  • Bawa-Khalfe, T.; Cheng, J.; Lin, S.H.; Ittmann, M.M.; Yeh, E.T.
    SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms (2010), J. Biol. Chem., 285, 25859-25866.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B70

Application

Application Comment Organism
medicine SENP1 overexpression induces transformation of the normal prostate gland and gradually facilitates the onset of high-grade prostatic intraepithelial neoplasiade. SUMOylation plays a critical role in prostate pathogenesis through induction of HIF1alpha-dependent angiogenesis and enhanced cell proliferation Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SUMO-hypoxia-inducible factor 1 conjugate + H2O Mus musculus deSUMOylation plays a critical role in prostate pathogenesis through induction of HIF1alpha-dependent angiogenesis and enhanced cell proliferation SUMO + hypoxia-inducible factor 1
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P59110
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-

Source Tissue

Source Tissue Comment Organism Textmining
prostate SENP1 modulates prostate epithelial cell proliferation Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SUMO-hypoxia-inducible factor 1 conjugate + H2O
-
 Mus musculus SUMO + hypoxia-inducible factor 1
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 ?
SUMO-hypoxia-inducible factor 1 conjugate + H2O deSUMOylation plays a critical role in prostate pathogenesis through induction of HIF1alpha-dependent angiogenesis and enhanced cell proliferation Mus musculus SUMO + hypoxia-inducible factor 1
-
 ?

Synonyms

Synonyms Comment Organism
SENP1
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 Mus musculus