3.4.22.B70: SENP1 peptidase

This is an abbreviated version, for detailed information about SENP1 peptidase, go to the full flat file.

Reaction

The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO-1, SUMO-2 and SUMO-3 from targeted proteins. Deconjugates SUMO-1 from homeodomain-interacting protein kinase 2. Deconjugates SUMO-1 from histone deacetylase 1, which decreases its transcriptional repression activity. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. =

Synonyms

C13orf22l, SENP, SENP1, sentrin-specific protease 1, sentrin/SUMO-specific protease 1, small ubiquitin-like modifier protein-specific protease 1, small ubiquitin-related modifier-specific isopeptidase, SUMO isopeptidase, SUMO protease, SUMO protein-specific protease 1, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 1, ubiquitin-specific protease-like 1, USPL1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B70 SENP1 peptidase

Source Tissue

Source Tissue on EC 3.4.22.B70 - SENP1 peptidase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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enzyme SENP1 levels are positively correlated with substrate Pin1 levels in human breast cancer specimens
Manually annotated by BRENDA team
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the enzyme expression is deregulated in cancers
Manually annotated by BRENDA team
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metastatic neuroblastoma tissue
Manually annotated by BRENDA team
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enzyme SENP1 is upregulated in pancreatic ductal adenocarcinoma tissues compared with adjacent normal tissues
Manually annotated by BRENDA team
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SENP1 modulates prostate epithelial cell proliferation
Manually annotated by BRENDA team
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elevation of SENP1 mRNA in prostate cancer cells as compared with normal prostate epithelial cells
Manually annotated by BRENDA team
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highest expression
Manually annotated by BRENDA team